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Dynamics of the DNA repair proteins WRN and BLM in the nucleoplasm and nucleoli

Overview of attention for article published in European Biophysics Journal, August 2014
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  • High Attention Score compared to outputs of the same age and source (85th percentile)

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2 Wikipedia pages

Citations

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4 Dimensions

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19 Mendeley
Title
Dynamics of the DNA repair proteins WRN and BLM in the nucleoplasm and nucleoli
Published in
European Biophysics Journal, August 2014
DOI 10.1007/s00249-014-0981-x
Pubmed ID
Authors

Kristian Moss Bendtsen, Martin Borch Jensen, Alfred May, Lene Juel Rasmussen, Ala Trusina, Vilhelm A. Bohr, Mogens H. Jensen

Abstract

We have investigated the mobility of two EGFP-tagged DNA repair proteins, WRN and BLM. In particular, we focused on the dynamics in two locations, the nucleoli and the nucleoplasm. We found that both WRN and BLM use a "DNA-scanning" mechanism, with rapid binding-unbinding to DNA resulting in effective diffusion. In the nucleoplasm WRN and BLM have effective diffusion coefficients of 1.62 and 1.34 μm(2)/s, respectively. Likewise, the dynamics in the nucleoli are also best described by effective diffusion, but with diffusion coefficients a factor of ten lower than in the nucleoplasm. From this large reduction in diffusion coefficient we were able to classify WRN and BLM as DNA damage scanners. In addition to WRN and BLM we also classified other DNA damage proteins and found they all fall into one of two categories. Either they are scanners, similar to WRN and BLM, with very low diffusion coefficients, suggesting a scanning mechanism, or they are almost freely diffusing, suggesting that they interact with DNA only after initiation of a DNA damage response.

Mendeley readers

The data shown below were compiled from readership statistics for 19 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 19 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 5 26%
Researcher 5 26%
Unspecified 2 11%
Other 2 11%
Professor > Associate Professor 2 11%
Other 3 16%
Readers by discipline Count As %
Agricultural and Biological Sciences 7 37%
Physics and Astronomy 4 21%
Unspecified 2 11%
Engineering 2 11%
Neuroscience 1 5%
Other 3 16%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 September 2014.
All research outputs
#3,500,494
of 12,225,829 outputs
Outputs from European Biophysics Journal
#53
of 289 outputs
Outputs of similar age
#80,311
of 270,250 outputs
Outputs of similar age from European Biophysics Journal
#1
of 7 outputs
Altmetric has tracked 12,225,829 research outputs across all sources so far. This one is in the 49th percentile – i.e., 49% of other outputs scored the same or lower than it.
So far Altmetric has tracked 289 research outputs from this source. They receive a mean Attention Score of 2.7. This one is in the 39th percentile – i.e., 39% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 270,250 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 66% of its contemporaries.
We're also able to compare this research output to 7 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them