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The potential of antisense oligonucleotide therapies for inherited childhood lung diseases

Overview of attention for article published in Molecular and Cellular Pediatrics, February 2018
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Title
The potential of antisense oligonucleotide therapies for inherited childhood lung diseases
Published in
Molecular and Cellular Pediatrics, February 2018
DOI 10.1186/s40348-018-0081-6
Pubmed ID
Authors

Kelly M. Martinovich, Nicole C. Shaw, Anthony Kicic, André Schultz, Sue Fletcher, Steve D. Wilton, Stephen M. Stick

Abstract

Antisense oligonucleotides are an emerging therapeutic option to treat diseases with known genetic origin. In the age of personalised medicines, antisense oligonucleotides can sometimes be designed to target and bypass or overcome a patient's genetic mutation, in particular those lesions that compromise normal pre-mRNA processing. Antisense oligonucleotides can alter gene expression through a variety of mechanisms as determined by the chemistry and antisense oligomer design. Through targeting the pre-mRNA, antisense oligonucleotides can alter splicing and induce a specific spliceoform or disrupt the reading frame, target an RNA transcript for degradation through RNaseH activation, block ribosome initiation of protein translation or disrupt miRNA function. The recent accelerated approval of eteplirsen (renamed Exondys 51™) by the Food and Drug Administration, for the treatment of Duchenne muscular dystrophy, and nusinersen, for the treatment of spinal muscular atrophy, herald a new and exciting era in splice-switching antisense oligonucleotide applications to treat inherited diseases. This review considers the potential of antisense oligonucleotides to treat inherited lung diseases of childhood with a focus on cystic fibrosis and disorders of surfactant protein metabolism.

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The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 114 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 114 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 25 22%
Student > Ph. D. Student 16 14%
Researcher 14 12%
Student > Bachelor 12 11%
Student > Doctoral Student 6 5%
Other 11 10%
Unknown 30 26%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 29 25%
Medicine and Dentistry 11 10%
Agricultural and Biological Sciences 10 9%
Chemistry 8 7%
Pharmacology, Toxicology and Pharmaceutical Science 7 6%
Other 15 13%
Unknown 34 30%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 February 2018.
All research outputs
#20,462,806
of 23,020,670 outputs
Outputs from Molecular and Cellular Pediatrics
#82
of 98 outputs
Outputs of similar age
#375,398
of 437,329 outputs
Outputs of similar age from Molecular and Cellular Pediatrics
#4
of 4 outputs
Altmetric has tracked 23,020,670 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 98 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.0. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 437,329 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 4 others from the same source and published within six weeks on either side of this one.