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Fungal strain matters: colony growth and bioactivity of the European medicinal polypores Fomes fomentarius, Fomitopsis pinicola and Piptoporus betulinus

Overview of attention for article published in AMB Express, January 2015
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63 Mendeley
Title
Fungal strain matters: colony growth and bioactivity of the European medicinal polypores Fomes fomentarius, Fomitopsis pinicola and Piptoporus betulinus
Published in
AMB Express, January 2015
DOI 10.1186/s13568-014-0093-0
Pubmed ID
Authors

Philipp Dresch, Maria Nives D´Aguanno, Katharina Rosam, Ulrike Grienke, Judith Maria Rollinger, Ursula Peintner

Abstract

Polypores have been applied in traditional Chinese medicine up to the present day, and are becoming more and more popular worldwide. They show a wide range of bioactivities including anti-cancer, anti-inflammatory, antiviral and immuno-enhancing effects. Their secondary metabolites have been the focus of many studies, but the importance of fungal strain for bioactivity and metabolite production has not been investigated so far for these Basidiomycetes. Therefore, we screened several strains from three medicinal polypore species from traditional European medicine: Fomes fomentarius, Fomitopsis pinicola and Piptoporus betulinus. A total of 22 strains were compared concerning their growth rates, optimum growth temperatures, as well as antimicrobial and antifungal properties of ethanolic fruit body extracts. The morphological identification of strains was confirmed based on rDNA ITS phylogenetic analyses. Our results showed that species delimitation is critical due to the presence of several distinct lineages, e.g. within the Fomes fomentarius species complex. Fungal strains within one lineage showed distinct differences in optimum growth temperatures, in secondary metabolite production, and accordingly, in their bioactivities. In general, F. pinicola and P. betulinus extracts exerted distinct antibiotic activities against Bacillus subtilis and Staphylococcus aureus at minimum inhibitory concentrations (MIC) ranging from 31-125 μg mL(-1); The antifungal activities of all three polypores against Aspergillus flavus, A. fumigatus, Absidia orchidis and Candida krusei were often strain-specific, ranging from 125-1000 μg mL(-1). Our results highlight that a reliable species identification, followed by an extensive screening for a 'best strain' is an essential prerequisite for the proper identification of bioactive material.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 63 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Japan 1 2%
Sweden 1 2%
Unknown 61 97%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 12 19%
Student > Ph. D. Student 11 17%
Researcher 9 14%
Student > Master 7 11%
Student > Doctoral Student 6 10%
Other 7 11%
Unknown 11 17%
Readers by discipline Count As %
Agricultural and Biological Sciences 24 38%
Biochemistry, Genetics and Molecular Biology 9 14%
Environmental Science 4 6%
Chemistry 3 5%
Engineering 3 5%
Other 8 13%
Unknown 12 19%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 May 2015.
All research outputs
#3,591,848
of 5,114,553 outputs
Outputs from AMB Express
#214
of 250 outputs
Outputs of similar age
#124,450
of 181,977 outputs
Outputs of similar age from AMB Express
#15
of 16 outputs
Altmetric has tracked 5,114,553 research outputs across all sources so far. This one is in the 16th percentile – i.e., 16% of other outputs scored the same or lower than it.
So far Altmetric has tracked 250 research outputs from this source. They receive a mean Attention Score of 2.1. This one is in the 11th percentile – i.e., 11% of its peers scored the same or lower than it.
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We're also able to compare this research output to 16 others from the same source and published within six weeks on either side of this one. This one is in the 6th percentile – i.e., 6% of its contemporaries scored the same or lower than it.