| Title |
DNA damage to spermatozoa has impacts on fertilization and pregnancy
|
|---|---|
| Published in |
Cell and Tissue Research, May 2005
|
| DOI | 10.1007/s00441-005-1097-5 |
| Pubmed ID | |
| Authors |
S. E. M. Lewis, R. J. Aitken |
| Abstract |
DNA damage in the male germ line has been associated with poor semen quality, low fertilization rates, impaired preimplantation development, increased abortion and an elevated incidence of disease in the offspring, including childhood cancer. The causes of this DNA damage are still uncertain but the major candidates are oxidative stress and aberrant apoptosis. The weight of evidence currently favours the former and, in keeping with this conclusion, positive results have been reported for antioxidant therapy both in vivo and in vitro. Resolving the causes of DNA damage in the male germ line will be essential if we are to prevent the generation of genetically damaged human embryos, particularly in the context of assisted conception therapy. |
Mendeley readers
The data shown below were compiled from readership statistics for 215 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Uruguay | 2 | <1% |
| Switzerland | 1 | <1% |
| Canada | 1 | <1% |
| Spain | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 209 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 41 | 19% |
| Researcher | 37 | 17% |
| Student > Bachelor | 21 | 10% |
| Student > Master | 16 | 7% |
| Student > Doctoral Student | 11 | 5% |
| Other | 38 | 18% |
| Unknown | 51 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 69 | 32% |
| Biochemistry, Genetics and Molecular Biology | 34 | 16% |
| Medicine and Dentistry | 28 | 13% |
| Veterinary Science and Veterinary Medicine | 7 | 3% |
| Engineering | 4 | 2% |
| Other | 14 | 7% |
| Unknown | 59 | 27% |
Attention Score in Context
This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 May 2022.
All research outputs
#3,482,272
of 23,924,386 outputs
Outputs from Cell and Tissue Research
#124
of 2,284 outputs
Outputs of similar age
#6,462
of 58,874 outputs
Outputs of similar age from Cell and Tissue Research
#2
of 22 outputs
Altmetric has tracked 23,924,386 research outputs across all sources so far. Compared to these this one has done well and is in the 84th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,284 research outputs from this source. They receive a mean Attention Score of 3.3. This one has done particularly well, scoring higher than 93% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 58,874 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 85% of its contemporaries.
We're also able to compare this research output to 22 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 95% of its contemporaries.