| Title |
On the structural definition of amyloid fibrils and other polypeptide aggregates
|
|---|---|
| Published in |
Cellular and Molecular Life Sciences, May 2007
|
| DOI | 10.1007/s00018-007-7110-2 |
| Pubmed ID | |
| Authors |
M. Fändrich |
| Abstract |
Amyloid fibrils occur inside the human body, associated with ageing or a group of diseases that includes, amongst others, Alzheimer's disease, atherosclerosis and type II diabetes. Many natural polypeptide chains are able to form amyloid fibrils in vivo or in vitro, and this ability has been suggested to represent an inherent consequence of the chemical structure of the polypeptide chain. Recent literature has provided a wealth of information about the structure of aggregates, precipitates, amyloid fibrils and other types of fibrillar polypeptide assemblies. However, the biophysical meaning associated with these terms can differ considerably depending on the context of their usage. This overview presents a structural comparison of amyloid fibrils and other types of polypeptide assemblies and defines amyloid fibrils, based on structural considerations, as fibrillar polypeptide aggregates with a cross-beta conformation. |
Mendeley readers
The data shown below were compiled from readership statistics for 282 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 2 | <1% |
| Portugal | 1 | <1% |
| Switzerland | 1 | <1% |
| Malaysia | 1 | <1% |
| Italy | 1 | <1% |
| India | 1 | <1% |
| United Kingdom | 1 | <1% |
| Canada | 1 | <1% |
| Spain | 1 | <1% |
| Other | 1 | <1% |
| Unknown | 271 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 75 | 27% |
| Student > Master | 40 | 14% |
| Researcher | 38 | 13% |
| Student > Bachelor | 34 | 12% |
| Professor | 15 | 5% |
| Other | 42 | 15% |
| Unknown | 38 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 80 | 28% |
| Biochemistry, Genetics and Molecular Biology | 43 | 15% |
| Chemistry | 43 | 15% |
| Physics and Astronomy | 14 | 5% |
| Engineering | 11 | 4% |
| Other | 46 | 16% |
| Unknown | 45 | 16% |
Attention Score in Context
This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 August 2021.
All research outputs
#3,460,684
of 23,794,258 outputs
Outputs from Cellular and Molecular Life Sciences
#571
of 4,151 outputs
Outputs of similar age
#8,289
of 72,217 outputs
Outputs of similar age from Cellular and Molecular Life Sciences
#5
of 39 outputs
Altmetric has tracked 23,794,258 research outputs across all sources so far. Compared to these this one has done well and is in the 84th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,151 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.0. This one has done well, scoring higher than 88% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 72,217 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 85% of its contemporaries.
We're also able to compare this research output to 39 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 74% of its contemporaries.