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Updates in Lupus Genetics

Overview of attention for article published in Current Rheumatology Reports, October 2017
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1 tweeter

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37 Mendeley
Title
Updates in Lupus Genetics
Published in
Current Rheumatology Reports, October 2017
DOI 10.1007/s11926-017-0695-z
Pubmed ID
Authors

Yun Deng, Betty P. Tsao

Abstract

Our understanding on genetic basis of SLE has been advanced through genome-wide association studies. We review recent progress in lupus genetics with a focus on SLE-associated loci that have been functionally characterized, and discuss the potential for clinical translation of genetics data. Over 100 loci have been confirmed to show robust association with SLE and many share with other immune-mediated diseases. Although causative variants captured at these established loci are limited, they guide biological studies of gene targets for functional characterization which highlight the importance of aberrant recognition of self-nucleic acid, type I interferon overproduction, and defective immune cell signaling underlying the pathogenesis of SLE. Increasing examples illustrate a predictive value of genetic findings in susceptibility/prognosis prediction, clinical classification, and pharmacological implication. Genetic findings provide a foundation for better understanding of disease pathogenic mechanisms and opportunities for target selection in lupus drug development.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 37 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 37 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 8 22%
Student > Ph. D. Student 5 14%
Student > Bachelor 5 14%
Student > Master 4 11%
Unspecified 4 11%
Other 11 30%
Readers by discipline Count As %
Medicine and Dentistry 15 41%
Biochemistry, Genetics and Molecular Biology 10 27%
Unspecified 6 16%
Immunology and Microbiology 2 5%
Neuroscience 1 3%
Other 3 8%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 January 2018.
All research outputs
#9,943,015
of 12,419,722 outputs
Outputs from Current Rheumatology Reports
#338
of 458 outputs
Outputs of similar age
#246,222
of 339,859 outputs
Outputs of similar age from Current Rheumatology Reports
#8
of 12 outputs
Altmetric has tracked 12,419,722 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 458 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.3. This one is in the 13th percentile – i.e., 13% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 339,859 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 15th percentile – i.e., 15% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 12 others from the same source and published within six weeks on either side of this one. This one is in the 8th percentile – i.e., 8% of its contemporaries scored the same or lower than it.