| Title |
Biotransformation of mulberroside A from Morus alba results in enhancement of tyrosinase inhibition
|
|---|---|
| Published in |
Journal of Industrial Microbiology & Biotechnology, April 2010
|
| DOI | 10.1007/s10295-010-0722-9 |
| Pubmed ID | |
| Authors |
Jeong-Keun Kim, Mijin Kim, Ssang-Goo Cho, Myung-Kyoo Kim, Suhng Wook Kim, Young-Hee Lim |
| Abstract |
Mulberroside A, a glycosylated stilbene, was isolated and identified from the ethanol extract of the roots of Morus alba. Oxyresveratrol, the aglycone of mulberroside A, was produced by enzymatic hydrolysis of mulberroside A using the commercial enzyme Pectinex. Mulberroside A and oxyresveratrol showed inhibitory activity against mushroom tyrosinase with an IC(50) of 53.6 and 0.49 microM, respectively. The tyrosinase inhibitory activity of oxyresveratrol was thus approximately 110-fold higher than that of mulberroside A. Inhibition kinetics showed mulberroside A to be a competitive inhibitor of mushroom tyrosinase with L-tyrosine and L-DOPA as substrate. Oxyresveratrol showed mixed inhibition and noncompetitive inhibition against L-tyrosine and L-DOPA, respectively, as substrate. The results indicate that the tyrosinase inhibitory activity of mulberroside A was greatly enhanced by the bioconversion process. |
Mendeley readers
The data shown below were compiled from readership statistics for 46 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Indonesia | 1 | 2% |
| Malaysia | 1 | 2% |
| Unknown | 44 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 8 | 17% |
| Student > Bachelor | 6 | 13% |
| Student > Ph. D. Student | 6 | 13% |
| Student > Postgraduate | 5 | 11% |
| Student > Doctoral Student | 4 | 9% |
| Other | 8 | 17% |
| Unknown | 9 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 20 | 43% |
| Medicine and Dentistry | 4 | 9% |
| Biochemistry, Genetics and Molecular Biology | 3 | 7% |
| Chemistry | 3 | 7% |
| Engineering | 2 | 4% |
| Other | 5 | 11% |
| Unknown | 9 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 November 2021.
All research outputs
#3,271,353
of 22,782,096 outputs
Outputs from Journal of Industrial Microbiology & Biotechnology
#87
of 1,302 outputs
Outputs of similar age
#12,830
of 95,081 outputs
Outputs of similar age from Journal of Industrial Microbiology & Biotechnology
#1
of 5 outputs
Altmetric has tracked 22,782,096 research outputs across all sources so far. Compared to these this one has done well and is in the 84th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,302 research outputs from this source. They receive a mean Attention Score of 4.2. This one has done well, scoring higher than 87% of its peers.
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We're also able to compare this research output to 5 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them