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A novel genomic signature predicting FDG uptake in diverse metastatic tumors

Overview of attention for article published in EJNMMI Research, January 2018
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Title
A novel genomic signature predicting FDG uptake in diverse metastatic tumors
Published in
EJNMMI Research, January 2018
DOI 10.1186/s13550-017-0355-3
Pubmed ID
Authors

Aurora Crespo-Jara, Maria Carmen Redal-Peña, Elena Maria Martinez-Navarro, Manuel Sureda, Francisco Jose Fernandez-Morejon, Francisco J. Garcia-Cases, Ramon Gonzalez Manzano, Antonio Brugarolas

Abstract

Building a universal genomic signature predicting the intensity of FDG uptake in diverse metastatic tumors may allow us to understand better the biological processes underlying this phenomenon and their requirements of glucose uptake. A balanced training set (n = 71) of metastatic tumors including some of the most frequent histologies, with matched PET/CT quantification measurements and whole human genome gene expression microarrays, was used to build the signature. Selection of microarray features was carried out exclusively on the basis of their strong association with FDG uptake (as measured by SUVmean35) by means of univariate linear regression. A thorough bioinformatics study of these genes was performed, and multivariable models were built by fitting several state of the art regression techniques to the training set for comparison. The 909 probes with the strongest association with the SUVmean35 (comprising 742 identifiable genes and 62 probes not matched to a symbol) were used to build the signature. Partial least squares using three components (PLS-3) was the best performing model in the training dataset cross-validation (root mean square error, RMSE = 0.443) and was validated further in an independent validation dataset (n = 13) obtaining a performance within the 95% CI of that obtained in the training dataset (RMSE = 0.645). Significantly overrepresented biological processes correlating with the SUVmean35 were identified beyond glycolysis, such as ribosome biogenesis and DNA replication (correlating with a higher SUVmean35) and cytoskeleton reorganization and autophagy (correlating with a lower SUVmean35). PLS-3 is a signature predicting accurately the intensity of FDG uptake in diverse metastatic tumors. FDG-PET might help in the design of specific targeted therapies directed to counteract the identified malignant biological processes more likely activated in a tumor as inferred from the SUVmean35 and also from its variations in response to antineoplastic treatments.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 7 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 7 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 3 43%
Student > Ph. D. Student 2 29%
Student > Postgraduate 1 14%
Student > Doctoral Student 1 14%
Readers by discipline Count As %
Medicine and Dentistry 5 71%
Nursing and Health Professions 1 14%
Pharmacology, Toxicology and Pharmaceutical Science 1 14%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 January 2018.
All research outputs
#11,011,162
of 12,390,159 outputs
Outputs from EJNMMI Research
#160
of 239 outputs
Outputs of similar age
#285,963
of 339,190 outputs
Outputs of similar age from EJNMMI Research
#1
of 1 outputs
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