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Negative regulators of cell death pathways in cancer: perspective on biomarkers and targeted therapies

Overview of attention for article published in Apoptosis, January 2018
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (68th percentile)
  • High Attention Score compared to outputs of the same age and source (88th percentile)

Mentioned by

1 tweeter
4 Wikipedia pages


12 Dimensions

Readers on

45 Mendeley
Negative regulators of cell death pathways in cancer: perspective on biomarkers and targeted therapies
Published in
Apoptosis, January 2018
DOI 10.1007/s10495-018-1440-4
Pubmed ID

Ali Razaghi, Kirsten Heimann, Patrick M. Schaeffer, Spencer B. Gibson


Cancer is a primary cause of human fatality and conventional cancer therapies, e.g., chemotherapy, are often associated with adverse side-effects, tumor drug-resistance, and recurrence. Molecularly targeted therapy, composed of small-molecule inhibitors and immunotherapy (e.g., monoclonal antibody and cancer vaccines), is a less harmful alternative being more effective against cancer cells whilst preserving healthy tissues. Drug-resistance, however, caused by negative regulation of cell death signaling pathways, is still a challenge. Circumvention of negative regulators of cell death pathways or development of predictive and response biomarkers is, therefore, quintessential. This review critically discusses the current state of knowledge on targeting negative regulators of cell death signaling pathways including apoptosis, ferroptosis, necroptosis, autophagy, and anoikis and evaluates the recent advances in clinical and preclinical research on biomarkers of negative regulators. It aims to provide a comprehensive platform for designing efficacious polytherapies including novel agents for restoring cell death signaling pathways or targeting alternative resistance pathways to improve the chances for antitumor responses. Overall, it is concluded that nonapoptotic cell death pathways are a potential research arena for drug discovery, development of novel biomarkers and targeted therapies.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 45 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 45 100%

Demographic breakdown

Readers by professional status Count As %
Unspecified 12 27%
Student > Bachelor 9 20%
Student > Doctoral Student 8 18%
Student > Master 4 9%
Student > Ph. D. Student 4 9%
Other 8 18%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 16 36%
Unspecified 14 31%
Agricultural and Biological Sciences 5 11%
Medicine and Dentistry 3 7%
Computer Science 3 7%
Other 4 9%

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 March 2018.
All research outputs
of 12,633,553 outputs
Outputs from Apoptosis
of 588 outputs
Outputs of similar age
of 429,031 outputs
Outputs of similar age from Apoptosis
of 9 outputs
Altmetric has tracked 12,633,553 research outputs across all sources so far. This one has received more attention than most of these and is in the 73rd percentile.
So far Altmetric has tracked 588 research outputs from this source. They receive a mean Attention Score of 3.3. This one has done well, scoring higher than 86% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 429,031 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 68% of its contemporaries.
We're also able to compare this research output to 9 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them