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Comparison of free α-tocopherol and α-tocopheryl acetate as sources of vitamin E in rats and humans

Overview of attention for article published in Lipids, September 1988
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  • Above-average Attention Score compared to outputs of the same age (58th percentile)
  • Average Attention Score compared to outputs of the same age and source

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2 tweeters

Citations

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Readers on

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11 Mendeley
Title
Comparison of free α-tocopherol and α-tocopheryl acetate as sources of vitamin E in rats and humans
Published in
Lipids, September 1988
DOI 10.1007/bf02536201
Pubmed ID
Authors

Graham W. Burton, Keith U. Ingold, David O. Foster, Shee C. Cheng, Ann Webb, Lise Hughes

Abstract

The uptake of alpha-tocopherol from 2R,4'R,8'R-alpha-tocopherol and 2R, 4'R, 8'R-alpha-tocopheryl acetate has been compared in rats and humans. The two forms of vitamin E were compared simultaneously in each subject (rat and human) by using a combination of deuterium-substitution and gas chromatography-mass spectrometry (GC-MS) to distinguish and measure the competitive uptake of alpha-tocopherol from an orally ingested mixture of the acetate and the free phenol forms. When rats were dosed in a manner analogous to that used in traditional bioassays, i.e., providing the two forms of vitamin E once daily in tocopherol-stripped corn oil for four successive days immediately prior to sacrifice, the net uptake of alpha-tocopherol from the free phenol form was only half that from the acetate. This result is consistent with the greater activity of the acetate that had been observed previously in bioassays. However, when the two forms of tocopherol were intubated into rats as a single dose mixed in with an aqueous bolus of standard laboratory diet, the amount of alpha-tocopherol taken up from the free form after 24 hr was very similar to that derived from the acetate. In five adult humans, competitive uptake studies of the two forms after a single dose taken with a meal showed that the amount of alpha-tocopherol from the free phenol form was equal to that from the acetate in plasma and red blood cells.(ABSTRACT TRUNCATED AT 250 WORDS)

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 11 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 11 100%

Demographic breakdown

Readers by professional status Count As %
Unspecified 3 27%
Student > Doctoral Student 3 27%
Student > Master 3 27%
Other 1 9%
Professor 1 9%
Other 0 0%
Readers by discipline Count As %
Unspecified 3 27%
Chemistry 3 27%
Biochemistry, Genetics and Molecular Biology 2 18%
Agricultural and Biological Sciences 1 9%
Medicine and Dentistry 1 9%
Other 1 9%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 September 2019.
All research outputs
#7,548,647
of 13,606,441 outputs
Outputs from Lipids
#1,265
of 1,600 outputs
Outputs of similar age
#111,950
of 279,717 outputs
Outputs of similar age from Lipids
#4
of 8 outputs
Altmetric has tracked 13,606,441 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,600 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.3. This one is in the 20th percentile – i.e., 20% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 279,717 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 58% of its contemporaries.
We're also able to compare this research output to 8 others from the same source and published within six weeks on either side of this one. This one has scored higher than 4 of them.