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Classic toxin-induced animal models of Parkinson’s disease: 6-OHDA and MPTP

Overview of attention for article published in Cell and Tissue Research, July 2004
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (70th percentile)
  • Good Attention Score compared to outputs of the same age and source (73rd percentile)

Mentioned by

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1 patent
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1 Wikipedia page

Citations

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624 Dimensions

Readers on

mendeley
605 Mendeley
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1 CiteULike
Title
Classic toxin-induced animal models of Parkinson’s disease: 6-OHDA and MPTP
Published in
Cell and Tissue Research, July 2004
DOI 10.1007/s00441-004-0938-y
Pubmed ID
Authors

Andreas Schober

Abstract

Neurological disorders in humans can be modeled in animals using standardized procedures that recreate specific pathogenic events and their behavioral outcomes. The development of animal models of Parkinson's disease (PD) is important to test new neuroprotective agents and strategies. Such animal models of PD have to mimic, at least partially, a Parkinson-like pathology and should reproduce specific features of the human disease. PD is characterized by massive degeneration of dopaminergic neurons in the substantia nigra, the loss of striatal dopaminergic fibers and a dramatic reduction of the striatal dopamine levels. The formation of cytoplasmic inclusion bodies (Lewy bodies) in surviving dopaminergic neurons represents the most important neuropathological feature of PD. Furthermore, the massive striatal dopamine deficiency causes easily detectable motor deficits in PD patients, including bradykinesia, rigidity, and resting tremor, which are the cardinal symptoms of PD. Over the years, a broad variety of experimental models of PD were developed and applied in diverse species. This review focuses on the two most common "classical" toxin-induced PD models, the 6-hydroxy-dopamine (6-OHDA model) and the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) model. Both neurotoxins selectively and rapidly destroy catecholaminergic neurons, whereas in humans the PD pathogenesis follows a progressive course over decades. This discrepancy reflects one important and principal point of weakness related to most animal models. This review discusses the most important properties of 6-OHDA and MPTP, their modes of administration, and critically examines advantages and limitations of selected animal models. The new genetic and environmental toxin models of PD (e.show $132#g. rotenone, paraquat, maneb) are discussed elsewhere in this "special issue."

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 605 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 7 1%
Brazil 6 <1%
United Kingdom 3 <1%
Germany 2 <1%
Australia 1 <1%
Macao 1 <1%
Korea, Republic of 1 <1%
France 1 <1%
Luxembourg 1 <1%
Other 1 <1%
Unknown 581 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 124 20%
Student > Master 96 16%
Student > Bachelor 84 14%
Researcher 73 12%
Student > Doctoral Student 33 5%
Other 85 14%
Unknown 110 18%
Readers by discipline Count As %
Agricultural and Biological Sciences 164 27%
Neuroscience 118 20%
Medicine and Dentistry 66 11%
Biochemistry, Genetics and Molecular Biology 48 8%
Pharmacology, Toxicology and Pharmaceutical Science 29 5%
Other 42 7%
Unknown 138 23%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 July 2021.
All research outputs
#5,700,702
of 23,839,820 outputs
Outputs from Cell and Tissue Research
#240
of 2,279 outputs
Outputs of similar age
#9,829
of 54,657 outputs
Outputs of similar age from Cell and Tissue Research
#3
of 15 outputs
Altmetric has tracked 23,839,820 research outputs across all sources so far. Compared to these this one has done well and is in the 76th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,279 research outputs from this source. They receive a mean Attention Score of 3.3. This one has done well, scoring higher than 85% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 54,657 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.
We're also able to compare this research output to 15 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 73% of its contemporaries.