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Classic toxin-induced animal models of Parkinson?s disease: 6-OHDA and MPTP

Overview of attention for article published in Cell & Tissue Research, July 2004
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  • Good Attention Score compared to outputs of the same age (66th percentile)
  • Good Attention Score compared to outputs of the same age and source (77th percentile)

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386 Mendeley
1 CiteULike
Classic toxin-induced animal models of Parkinson?s disease: 6-OHDA and MPTP
Published in
Cell & Tissue Research, July 2004
DOI 10.1007/s00441-004-0938-y
Pubmed ID

Andreas Schober


Neurological disorders in humans can be modeled in animals using standardized procedures that recreate specific pathogenic events and their behavioral outcomes. The development of animal models of Parkinson's disease (PD) is important to test new neuroprotective agents and strategies. Such animal models of PD have to mimic, at least partially, a Parkinson-like pathology and should reproduce specific features of the human disease. PD is characterized by massive degeneration of dopaminergic neurons in the substantia nigra, the loss of striatal dopaminergic fibers and a dramatic reduction of the striatal dopamine levels. The formation of cytoplasmic inclusion bodies (Lewy bodies) in surviving dopaminergic neurons represents the most important neuropathological feature of PD. Furthermore, the massive striatal dopamine deficiency causes easily detectable motor deficits in PD patients, including bradykinesia, rigidity, and resting tremor, which are the cardinal symptoms of PD. Over the years, a broad variety of experimental models of PD were developed and applied in diverse species. This review focuses on the two most common "classical" toxin-induced PD models, the 6-hydroxy-dopamine (6-OHDA model) and the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) model. Both neurotoxins selectively and rapidly destroy catecholaminergic neurons, whereas in humans the PD pathogenesis follows a progressive course over decades. This discrepancy reflects one important and principal point of weakness related to most animal models. This review discusses the most important properties of 6-OHDA and MPTP, their modes of administration, and critically examines advantages and limitations of selected animal models. The new genetic and environmental toxin models of PD (e.show $132#g. rotenone, paraquat, maneb) are discussed elsewhere in this "special issue."

Mendeley readers

The data shown below were compiled from readership statistics for 386 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 8 2%
Brazil 6 2%
Germany 3 <1%
United Kingdom 3 <1%
Poland 1 <1%
Australia 1 <1%
Macao 1 <1%
Luxembourg 1 <1%
France 1 <1%
Other 1 <1%
Unknown 360 93%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 90 23%
Student > Master 63 16%
Researcher 60 16%
Student > Bachelor 56 15%
Student > Doctoral Student 25 6%
Other 92 24%
Readers by discipline Count As %
Agricultural and Biological Sciences 158 41%
Neuroscience 73 19%
Medicine and Dentistry 59 15%
Unspecified 33 9%
Biochemistry, Genetics and Molecular Biology 24 6%
Other 39 10%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 August 2017.
All research outputs
of 11,638,207 outputs
Outputs from Cell & Tissue Research
of 1,478 outputs
Outputs of similar age
of 257,186 outputs
Outputs of similar age from Cell & Tissue Research
of 31 outputs
Altmetric has tracked 11,638,207 research outputs across all sources so far. This one is in the 49th percentile – i.e., 49% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,478 research outputs from this source. They receive a mean Attention Score of 2.6. This one is in the 49th percentile – i.e., 49% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 257,186 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 66% of its contemporaries.
We're also able to compare this research output to 31 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 77% of its contemporaries.