Title |
Dietary Glucosinolates Sulforaphane, Phenethyl Isothiocyanate, Indole-3-Carbinol/3,3′-Diindolylmethane: Antioxidative Stress/Inflammation, Nrf2, Epigenetics/Epigenomics and In Vivo Cancer Chemopreventive Efficacy
|
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Published in |
Current Pharmacology Reports, January 2015
|
DOI | 10.1007/s40495-015-0017-y |
Pubmed ID | |
Authors |
Francisco Fuentes, Ximena Paredes-Gonzalez, Ah-Ng Tony Kong |
Abstract |
Glucosinolates are a group of sulfur-containing glycosides found in many plant species, including cruciferous vegetables such as broccoli, cabbage, brussels sprouts, and cauliflower. Accumulating evidence increasingly supports the beneficial effects of dietary glucosinolates on overall health, including as potential anti-cancer agents, because of their role in the prevention of the initiation of carcinogenesis via the induction of cellular defense detoxifying/antioxidant enzymes and their epigenetic mechanisms, including modification of the CpG methylation of cancer-related genes, histone modification regulation and changes in the expression of miRNAs. In this context, the defense mechanism mediated by Nrf2-antioxidative stress and anti-inflammatory signaling pathways can contribute to cellular protection against oxidative stress and reactive metabolites of carcinogens. In this review, we summarize the cancer chemopreventive role of naturally occurring glucosinolate derivatives as inhibitors of carcinogenesis, with particular emphasis on specific molecular targets and epigenetic alterations in in vitro and in vivo human cancer animal models. |
X Demographics
Geographical breakdown
Country | Count | As % |
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France | 1 | 17% |
Argentina | 1 | 17% |
Unknown | 4 | 67% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 5 | 83% |
Practitioners (doctors, other healthcare professionals) | 1 | 17% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | <1% |
Unknown | 158 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 26 | 16% |
Student > Master | 22 | 14% |
Researcher | 18 | 11% |
Student > Ph. D. Student | 17 | 11% |
Student > Postgraduate | 8 | 5% |
Other | 27 | 17% |
Unknown | 41 | 26% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 30 | 19% |
Agricultural and Biological Sciences | 30 | 19% |
Medicine and Dentistry | 13 | 8% |
Pharmacology, Toxicology and Pharmaceutical Science | 10 | 6% |
Nursing and Health Professions | 6 | 4% |
Other | 17 | 11% |
Unknown | 53 | 33% |