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Dietary Glucosinolates Sulforaphane, Phenethyl Isothiocyanate, Indole-3-Carbinol/3,3′-Diindolylmethane: Antioxidative Stress/Inflammation, Nrf2, Epigenetics/Epigenomics and In Vivo Cancer…

Overview of attention for article published in Current Pharmacology Reports, January 2015
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Title
Dietary Glucosinolates Sulforaphane, Phenethyl Isothiocyanate, Indole-3-Carbinol/3,3′-Diindolylmethane: Antioxidative Stress/Inflammation, Nrf2, Epigenetics/Epigenomics and In Vivo Cancer Chemopreventive Efficacy
Published in
Current Pharmacology Reports, January 2015
DOI 10.1007/s40495-015-0017-y
Pubmed ID
Authors

Francisco Fuentes, Ximena Paredes-Gonzalez, Ah-Ng Tony Kong

Abstract

Glucosinolates are a group of sulfur-containing glycosides found in many plant species, including cruciferous vegetables such as broccoli, cabbage, brussels sprouts, and cauliflower. Accumulating evidence increasingly supports the beneficial effects of dietary glucosinolates on overall health, including as potential anti-cancer agents, because of their role in the prevention of the initiation of carcinogenesis via the induction of cellular defense detoxifying/antioxidant enzymes and their epigenetic mechanisms, including modification of the CpG methylation of cancer-related genes, histone modification regulation and changes in the expression of miRNAs. In this context, the defense mechanism mediated by Nrf2-antioxidative stress and anti-inflammatory signaling pathways can contribute to cellular protection against oxidative stress and reactive metabolites of carcinogens. In this review, we summarize the cancer chemopreventive role of naturally occurring glucosinolate derivatives as inhibitors of carcinogenesis, with particular emphasis on specific molecular targets and epigenetic alterations in in vitro and in vivo human cancer animal models.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 71 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 1%
Unknown 70 99%

Demographic breakdown

Readers by professional status Count As %
Student > Master 14 20%
Student > Bachelor 14 20%
Researcher 11 15%
Unspecified 8 11%
Student > Ph. D. Student 6 8%
Other 18 25%
Readers by discipline Count As %
Agricultural and Biological Sciences 15 21%
Unspecified 14 20%
Biochemistry, Genetics and Molecular Biology 12 17%
Medicine and Dentistry 11 15%
Pharmacology, Toxicology and Pharmaceutical Science 5 7%
Other 14 20%