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YAP Promotes Migration and Invasion of Human Glioma Cells

Overview of attention for article published in Journal of Molecular Neuroscience, January 2018
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2 tweeters

Citations

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15 Mendeley
Title
YAP Promotes Migration and Invasion of Human Glioma Cells
Published in
Journal of Molecular Neuroscience, January 2018
DOI 10.1007/s12031-017-1018-6
Pubmed ID
Authors

Yu Zhang, Peng Xie, Xu Wang, Peng Pan, Yan Wang, Hao Zhang, Yu Dong, Yi Shi, Yang Jiang, Rutong Yu, Xiuping Zhou

Abstract

Previously, we have reported that Yes-associated protein (YAP) is upregulated in human glioma tissues and its level is positively correlated with patient prognosis. However, the role and mechanism of YAP in the highly invasive nature of human gliomas were largely unknown. In this study, examined by wound healing assay, transwell assay, or live-imaging, we found that YAP downregulation inhibited glioma cell migration and invasion, while YAP over-expression promoted them. Interestingly, the above effect of YAP on immortalized glioma cells was recapitulated in cultured primary glioma cells. In addition, the protein level of N-cadherin and Twist, two important proteins involved in tumor invasion, increased after YAP over-expression. Meanwhile, YAP over-expression significantly increased the F-actin level and changed the distribution of F-actin, leading to cytoskeletal reorganization, which plays an important role in cell motility. Furthermore, the promotion effect of YAP over-expression on glioma cell migration and invasion was partially abolished by Twist downregulation. Taken together, our findings show that YAP contributes to glioma cell migration and invasion by regulating N-cadherin and Twist, as well as cytoskeletal reorganization.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 15 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 15 100%

Demographic breakdown

Readers by professional status Count As %
Unspecified 3 20%
Student > Bachelor 3 20%
Student > Master 3 20%
Student > Ph. D. Student 3 20%
Student > Doctoral Student 1 7%
Other 2 13%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 7 47%
Unspecified 3 20%
Agricultural and Biological Sciences 2 13%
Medicine and Dentistry 1 7%
Neuroscience 1 7%
Other 1 7%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 August 2018.
All research outputs
#10,694,248
of 13,444,601 outputs
Outputs from Journal of Molecular Neuroscience
#661
of 1,012 outputs
Outputs of similar age
#277,644
of 385,261 outputs
Outputs of similar age from Journal of Molecular Neuroscience
#14
of 29 outputs
Altmetric has tracked 13,444,601 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,012 research outputs from this source. They receive a mean Attention Score of 3.0. This one is in the 21st percentile – i.e., 21% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 385,261 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 15th percentile – i.e., 15% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 29 others from the same source and published within six weeks on either side of this one. This one is in the 34th percentile – i.e., 34% of its contemporaries scored the same or lower than it.