Shortly after, an interesting paper with a different model (beta cell O/E and KO of Ubc9 - the SUMO-conjugating enzyme) showed something intriguing. Increased SUMOylation was protective against cell death and prevented diabetes in response to STZ. 5/17 ht
Role of (de)SUMOylation in facilitating insulin secretion, and in exocytosis in general, was confirmed by others… /4 https://t.co/DEvtPp0D2t https://t.co/5MqGFC1zmX
Both conditional ablation and overexpression of E2 SUMO-conjugating enzyme (UBC9) in mouse pancreatic beta cells result in impaired beta cell function #Diabetes #NRF2 #SUMOylation #UBC9 #Insulinsecretion https://t.co/oLfGsMcN8w https://t.co/Hm3vCFthRl
RT @DiabetologiaJnl: Both conditional ablation and overexpression of E2 SUMO-conjugating enzyme (UBC9) in mouse pancreatic beta cells resul…
RT @DiabetologiaJnl: Both conditional ablation and overexpression of E2 SUMO-conjugating enzyme (UBC9) in mouse pancreatic beta cells resul…
Both conditional ablation and overexpression of E2 SUMO-conjugating enzyme (UBC9) in mouse pancreatic beta cells result in impaired beta cell function #Diabetes #NRF2 #SUMOylation #UBC9 #Insulinsecretion https://t.co/oLfGsMcN8w https://t.co/mD0DW5KUZg
Both Conditional Ablation & Overexpression of E2 SUMO-Conjugating Enzyme in Mouse Pancreatic Beta Cells Result in Impaired Beta Cell Function @ULBruxelles https://t.co/luByUo8e3T
RT @TKTLam: In vivo assessment of SUMOylation function in beta cells @DiabetologiaJnl ... https://t.co/xNKpnMBkf6
RT @TKTLam: In vivo assessment of SUMOylation function in beta cells @DiabetologiaJnl ... https://t.co/xNKpnMBkf6
RT @bcellorg: Excited to see this paper out. Consistent with much of what we’ve seen over the last 8-10 years (with new info too). Commenta…
Excited to see this paper out. Consistent with much of what we’ve seen over the last 8-10 years (with new info too). Commentary coming soon. https://t.co/TJIn2DOhPK
In vivo assessment of SUMOylation function in beta cells @DiabetologiaJnl ... https://t.co/xNKpnMBkf6