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Molecular basis of embryonic stem cell self-renewal: from signaling pathways to pluripotency network

Overview of attention for article published in Cellular & Molecular Life Sciences, January 2015
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (84th percentile)
  • High Attention Score compared to outputs of the same age and source (94th percentile)

Mentioned by

blogs
1 blog
twitter
3 tweeters

Citations

dimensions_citation
51 Dimensions

Readers on

mendeley
146 Mendeley
Title
Molecular basis of embryonic stem cell self-renewal: from signaling pathways to pluripotency network
Published in
Cellular & Molecular Life Sciences, January 2015
DOI 10.1007/s00018-015-1833-2
Pubmed ID
Authors

Guanyi Huang, Shoudong Ye, Xingliang Zhou, Dahai Liu, Qi-Long Ying

Abstract

Embryonic stem cells (ESCs) can be maintained in culture indefinitely while retaining the capacity to generate any type of cell in the body, and therefore not only hold great promise for tissue repair and regeneration, but also provide a powerful tool for modeling human disease and understanding biological development. In order to fulfill the full potential of ESCs, it is critical to understand how ESC fate, whether to self-renew or to differentiate into specialized cells, is regulated. On the molecular level, ESC fate is controlled by the intracellular transcriptional regulatory networks that respond to various extrinsic signaling stimuli. In this review, we discuss and compare important signaling pathways in the self-renewal and differentiation of mouse, rat, and human ESCs with an emphasis on how these pathways integrate into ESC-specific transcription circuitries. This will be beneficial for understanding the common and conserved mechanisms that govern self-renewal, and for developing novel culture conditions that support ESC derivation and maintenance.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 146 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 2 1%
United States 2 1%
Malaysia 1 <1%
France 1 <1%
Poland 1 <1%
Brazil 1 <1%
Japan 1 <1%
United Kingdom 1 <1%
Unknown 136 93%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 40 27%
Student > Master 29 20%
Researcher 22 15%
Student > Bachelor 20 14%
Unspecified 11 8%
Other 24 16%
Readers by discipline Count As %
Agricultural and Biological Sciences 66 45%
Biochemistry, Genetics and Molecular Biology 40 27%
Unspecified 14 10%
Medicine and Dentistry 7 5%
Engineering 6 4%
Other 13 9%

Attention Score in Context

This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 June 2015.
All research outputs
#1,619,493
of 12,227,808 outputs
Outputs from Cellular & Molecular Life Sciences
#236
of 2,527 outputs
Outputs of similar age
#40,925
of 270,223 outputs
Outputs of similar age from Cellular & Molecular Life Sciences
#5
of 75 outputs
Altmetric has tracked 12,227,808 research outputs across all sources so far. Compared to these this one has done well and is in the 86th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,527 research outputs from this source. They receive a mean Attention Score of 3.9. This one has done well, scoring higher than 87% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 270,223 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 84% of its contemporaries.
We're also able to compare this research output to 75 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 94% of its contemporaries.