Title |
Iodine-Containing Mass-Defect-Tuned Dendrimers for Use as Internal Mass Spectrometry Calibrants
|
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Published in |
Journal of the American Society for Mass Spectrometry, December 2017
|
DOI | 10.1007/s13361-017-1849-y |
Pubmed ID | |
Authors |
Joseph A. Giesen, Benjamin J. Diament, Scott M. Grayson |
Abstract |
Calibrants based on synthetic dendrimers have been recently proposed as a versatile alternative to peptides and proteins for both MALDI and ESI mass spectrometry calibration. Because of their modular synthetic platform, dendrimer calibrants are particularly amenable to tailoring for specific applications. Utilizing this versatility, a set of dendrimers has been designed as an internal calibrant with a tailored mass defect to differentiate them from the majority of natural peptide analytes. This was achieved by incorporating a tris-iodinated aromatic core as an initiator for the dendrimer synthesis, thereby affording multiple calibration points (m/z range 600-2300) with an optimized mass-defect offset relative to all peptides composed of the 20 most common proteinogenic amino acids. Graphical abstract ᅟ. |
X Demographics
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United States | 1 | 50% |
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Demographic breakdown
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Science communicators (journalists, bloggers, editors) | 1 | 50% |
Mendeley readers
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Demographic breakdown
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Researcher | 1 | 11% |
Lecturer | 1 | 11% |
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Unknown | 3 | 33% |
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Unknown | 4 | 44% |