@LifeboatHQ Unfortunately this is not true - both insulin sensitivity and insulin resistance are associated with longevity, as both result in reduced mTOR pathway signaling eg https://t.co/hUz7AUkYBd
RT @SilkeLeFay: #diabetes #endocrine #health #longevity #agedcare #gerontology #NCDs Diminished mTOR signaling: a common mode of action…
#diabetes #endocrine #health #longevity #agedcare #gerontology #NCDs Diminished mTOR signaling: a common mode of action for endocrine longevity factors mTOR is reduced by EGCG, apigenin and 1, 25(OH)2D3, and increased by environmental toxins (BPA). ht
@LaplanteMathieu It's an interesting concept we and Dr. Blagosklonny have previously discussed - https://t.co/hUz7AUkYBd and https://t.co/6WOmkQ49Bm
RT @LammingLab: @ethanjweiss For more on the insulin sensitivity/resistance and longevity paradox, a review I wrote a few years ago: https:…
@ethanjweiss For more on the insulin sensitivity/resistance and longevity paradox, a review I wrote a few years ago: https://t.co/hUz7AUkYBd
@Aging_Scientist @Teresavalencak @mjsteinbaugh @DMSabatini @StevenAustad @mkaeberlein @jpsenescence As mentioned in passing in my 2014 review, reduction of the GH effector IGF-1 alone does not increase lifespan. https://t.co/gfsQw7KoCJ
RT @LammingLab: @Maratosflier @JimJohnsonSci @adamjshay @bijans @DShaywitz Evidence remains contradictory and tissue effects, downstream pa…
@Maratosflier @JimJohnsonSci @adamjshay @bijans @DShaywitz Evidence remains contradictory and tissue effects, downstream pathways and role of igf1 all factors. my 2014 review https://t.co/g1Xq1Sjr3F
Last but certainly not least, a recent review article: http://t.co/EqP4dtSCM6
Cool news on trials of a PI3K inhibitor for diabetes http://t.co/RoWku8I6kK. Could PI3K inhibition extend lifespan? http://t.co/SwSyxMQP4D
Nice OA paper by my friend Dudley Lamming @ UW-Madison on mTOR signaling: http://t.co/N8ijCiUI5G