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An aptamer-based biosensor for detection of doxorubicin by electrochemical impedance spectroscopy

Overview of attention for article published in Analytical & Bioanalytical Chemistry, December 2017
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (64th percentile)
  • High Attention Score compared to outputs of the same age and source (92nd percentile)

Mentioned by

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5 tweeters
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1 Facebook page

Citations

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8 Dimensions

Readers on

mendeley
21 Mendeley
Title
An aptamer-based biosensor for detection of doxorubicin by electrochemical impedance spectroscopy
Published in
Analytical & Bioanalytical Chemistry, December 2017
DOI 10.1007/s00216-017-0786-8
Pubmed ID
Authors

Nicole Bahner, Peggy Reich, Dieter Frense, Marcus Menger, Katharina Schieke, Dieter Beckmann

Abstract

An aptamer-based biosensor was developed for the detection of doxorubicin using electrochemical impedance spectroscopy. Doxorubicin and its 14-dehydroxylated version daunorubicin are anthracyclines often used in cancer treatment. Due to their mutagenic and cardiotoxic effects, detection in groundwater is desirable. We developed a biosensor using the daunorubicin-binding aptamer as biological recognition element. The aptamer was successfully co-immobilized with mercaptohexanol on gold and a density of 1.3*1013 ± 2.4*1012 aptamer molecules per cm2 was achieved. The binding of doxorubicin to the immobilized aptamer was detected by electrochemical impedance spectroscopy. The principle is based on the inhibition of electron transfer between electrode and ferro-/ferricyanide in solution caused by the binding of doxorubicin to the immobilized aptamer. A linear relationship between the charge transfer resistance (R ct ) and the doxorubicin concentration was obtained over the range of 31 nM to 125 nM doxorubicin, with an apparent binding constant of 64 nM and a detection limit of 28 nM. With the advantages of high sensitivity, selectivity, and simple sensor construction, this method shows a high potential of impedimetric aptasensors in environmental monitoring. Graphical abstract Measurement chamber and immobilization principle for the detection of doxorubicin by electrochemical impedance spectroscopy.

Twitter Demographics

The data shown below were collected from the profiles of 5 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 21 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 21 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 7 33%
Researcher 5 24%
Student > Master 3 14%
Student > Bachelor 2 10%
Student > Doctoral Student 2 10%
Other 2 10%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 6 29%
Unspecified 4 19%
Engineering 4 19%
Agricultural and Biological Sciences 4 19%
Chemistry 2 10%
Other 1 5%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 September 2018.
All research outputs
#3,706,527
of 12,698,622 outputs
Outputs from Analytical & Bioanalytical Chemistry
#712
of 4,711 outputs
Outputs of similar age
#133,159
of 386,219 outputs
Outputs of similar age from Analytical & Bioanalytical Chemistry
#14
of 194 outputs
Altmetric has tracked 12,698,622 research outputs across all sources so far. This one is in the 49th percentile – i.e., 49% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,711 research outputs from this source. They receive a mean Attention Score of 2.5. This one has gotten more attention than average, scoring higher than 64% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 386,219 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 64% of its contemporaries.
We're also able to compare this research output to 194 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 92% of its contemporaries.