Title |
68Ga-DOTA-Siglec-9 PET/CT imaging of peri-implant tissue responses and staphylococcal infections
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Published in |
EJNMMI Research, August 2014
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DOI | 10.1186/s13550-014-0045-3 |
Pubmed ID | |
Authors |
Helena Ahtinen, Julia Kulkova, Laura Lindholm, Erkki Eerola, Antti J Hakanen, Niko Moritz, Mirva Söderström, Tiina Saanijoki, Sirpa Jalkanen, Anne Roivainen, Hannu T Aro |
Abstract |
Staphylococcus epidermidis (S. epidermidis) has emerged as one of the leading pathogens of biomaterial-related infections. Vascular adhesion protein-1 (VAP-1) is an inflammation-inducible endothelial molecule controlling extravasation of leukocytes. Sialic acid-binding immunoglobulin-like lectin 9 (Siglec-9) is a leukocyte ligand of VAP-1. We hypothesized that (68)Ga-labeled 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid-conjugated Siglec-9 motif containing peptide ((68)Ga-DOTA-Siglec-9) could detect inflammatory response due to S. epidermidis peri-implant infection by positron emission tomography (PET). |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Netherlands | 2 | 5% |
Unknown | 42 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 11 | 25% |
Student > Master | 6 | 14% |
Student > Ph. D. Student | 6 | 14% |
Student > Bachelor | 3 | 7% |
Student > Doctoral Student | 2 | 5% |
Other | 9 | 20% |
Unknown | 7 | 16% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 11 | 25% |
Agricultural and Biological Sciences | 5 | 11% |
Pharmacology, Toxicology and Pharmaceutical Science | 4 | 9% |
Chemistry | 4 | 9% |
Biochemistry, Genetics and Molecular Biology | 2 | 5% |
Other | 8 | 18% |
Unknown | 10 | 23% |