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Efficient production and secretion of oxaloacetate from Halomonas sp. KM-1 under aerobic conditions

Overview of attention for article published in AMB Express, November 2017
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (65th percentile)
  • Good Attention Score compared to outputs of the same age and source (79th percentile)

Mentioned by

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1 tweeter
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1 patent

Citations

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2 Dimensions

Readers on

mendeley
20 Mendeley
Title
Efficient production and secretion of oxaloacetate from Halomonas sp. KM-1 under aerobic conditions
Published in
AMB Express, November 2017
DOI 10.1186/s13568-017-0516-9
Pubmed ID
Authors

Asuka Hannya, Taku Nishimura, Isao Matsushita, Jun Tsubota, Yoshikazu Kawata

Abstract

The alkaliphilic, halophilic bacterium Halomonas sp. KM-1 can utilize glucose for the intracellular storage of the bioplastic poly-(R)-3-hydroxybutyric acid (PHB) and extracellular secretion of pyruvate under aerobic conditions. In this study, we investigated the effects of sodium chloride concentration on PHB accumulation and pyruvate secretion in the KM-1 strain and, unexpectedly, observed that oxaloacetate, an important intermediate chemical in the TCA cycle, glycogenesis, and aspartic acid biosynthesis, was secreted. We then further analyzed oxaloacetate productivity after changing the sodium chloride additive concentration, additive time-shift, and culture temperature. In 42-h batch-cultivation experiments, we found that wild-type Halomonas sp. KM-1 secreted 39.0 g/L oxaloacetate at a rate of 0.93 g/(L h). The halophilic bacteria Halomonas has already gained attention for industrial chemical-production processes owing to its unique properties, such as contamination-free culture conditions and a tolerance for high substrate concentrations. Moreover, no commercial scale oxaloacetate production was previously reported to result from bacterial fermentation. Oxaloacetate is an important intermediate chemical in biosynthesis and is used as a health food based on its role in energy synthesis. Thus, these data provided important insights into the production of oxaloacetate and other derivative chemicals using this strain.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 20 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 20 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 4 20%
Student > Ph. D. Student 4 20%
Student > Bachelor 3 15%
Researcher 2 10%
Other 1 5%
Other 1 5%
Unknown 5 25%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 6 30%
Agricultural and Biological Sciences 2 10%
Chemical Engineering 1 5%
Philosophy 1 5%
Immunology and Microbiology 1 5%
Other 1 5%
Unknown 8 40%

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 April 2019.
All research outputs
#4,413,491
of 14,798,224 outputs
Outputs from AMB Express
#98
of 932 outputs
Outputs of similar age
#136,757
of 403,378 outputs
Outputs of similar age from AMB Express
#21
of 104 outputs
Altmetric has tracked 14,798,224 research outputs across all sources so far. This one has received more attention than most of these and is in the 69th percentile.
So far Altmetric has tracked 932 research outputs from this source. They receive a mean Attention Score of 2.1. This one has done well, scoring higher than 89% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 403,378 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 65% of its contemporaries.
We're also able to compare this research output to 104 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 79% of its contemporaries.