Title |
GSK3β Controls mTOR and Prosurvival Signaling in Neurons
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Published in |
Molecular Neurobiology, November 2017
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DOI | 10.1007/s12035-017-0823-9 |
Pubmed ID | |
Authors |
Malgorzata Urbanska, Agata Gozdz, Matylda Macias, Iwona A. Cymerman, Ewa Liszewska, Ilona Kondratiuk, Herman Devijver, Benoit Lechat, Fred Van Leuven, Jacek Jaworski |
Abstract |
Glycogen synthase kinases-3β (GSK3β) is a key regulator of cell homeostasis. In neurons, GSK3β contributes to control of neuronal transmission and plasticity. Despite extensive studies in non-neuronal cells, crosstalk between GSK3β and other signaling pathways remains not well defined in neurons. In the present study, we report that GSK3β positively affected the activity of effectors of mammalian target of rapamycin complex 1 (mTORC1) and complex 2 (mTORC2), in mature neurons in vitro and in vivo. GSK3β also promoted prosurvival signaling and attenuated kainic acid-induced apoptosis. Our study identified GSK3β as a positive regulator of prosurvival signaling, including the mTOR pathway, and indicates the possible neuroprotective role of GSK3β in models of pharmacologically induced excitotoxicity. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 2 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 27 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 5 | 19% |
Student > Bachelor | 3 | 11% |
Researcher | 3 | 11% |
Professor > Associate Professor | 2 | 7% |
Student > Master | 2 | 7% |
Other | 4 | 15% |
Unknown | 8 | 30% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 9 | 33% |
Neuroscience | 3 | 11% |
Medicine and Dentistry | 3 | 11% |
Environmental Science | 1 | 4% |
Agricultural and Biological Sciences | 1 | 4% |
Other | 3 | 11% |
Unknown | 7 | 26% |