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Safety, pharmacokinetics, metabolism and radiation dosimetry of 18F-tetrafluoroborate (18F-TFB) in healthy human subjects

Overview of attention for article published in EJNMMI Research, October 2017
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Title
Safety, pharmacokinetics, metabolism and radiation dosimetry of 18F-tetrafluoroborate (18F-TFB) in healthy human subjects
Published in
EJNMMI Research, October 2017
DOI 10.1186/s13550-017-0337-5
Pubmed ID
Authors

Huailei Jiang, Nicholas R. Schmit, Alex R. Koenen, Aditya Bansal, Mukesh K. Pandey, Robert B. Glynn, Bradley J. Kemp, Kera L. Delaney, Angela Dispenzieri, Jamie N. Bakkum-Gamez, Kah-Whye Peng, Stephen J. Russell, Tina M. Gunderson, Val J. Lowe, Timothy R. DeGrado

Abstract

(18)F-Tetrafluoroborate ((18)F-TFB) is a promising iodide analog for PET imaging of thyroid cancer and sodium/iodide symporter (NIS) reporter activity in viral therapy applications. The aim of this study was to evaluate the safety, pharmacokinetics, biodistribution, and radiation dosimetry of high-specific activity (18)F-TFB in healthy human subjects. (18)F-TFB was synthesized with specific activity of 3.2 ± 1.3 GBq/μmol (at the end of synthesis). Dynamic and whole-body static PET/CT scans over 4 h were performed after intravenous administration of (18)F-TFB (333-407 MBq) in four female and four male healthy volunteers (35 ± 11 years old). Samples of venous blood and urine were collected over the imaging period and analyzed by ion-chromatography HPLC to determine tracer stability. Vital signs and clinical laboratory safety assays were measured to evaluate safety. (18)F-TFB administration was well tolerated with no significant findings on vital signs and no clinically meaningful changes in clinical laboratory assays. Left-ventricular blood pool time-activity curves showed a multi-phasic blood clearance of (18)F-radioactivity with the two rapid clearance phases over the first 20 min, followed by a slower clearance phase. HPLC analysis showed insignificant (18)F-labeled metabolites in the blood and urine over the length of the study (4 h). High uptakes were seen in the thyroid, stomach, salivary glands, and bladder. Urinary clearance of (18)F-TFB was prominent. Metabolic stability was evidenced by low accumulation of (18)F-radioactivity in the bone. Effective doses were 0.036 mSv/MBq in males and 0.064 mSv/MBq in females (p = 0.08, not significant). This initial study in healthy human subjects showed (18)F-TFB was safe and distributed in the human body similar to other iodide analogs. These data support further translational studies with (18)F-TFB as NIS gene reporter and imaging biomarker for thyroid cancer and other disease processes that import iodide.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 41 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 41 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 7 17%
Student > Ph. D. Student 6 15%
Student > Master 5 12%
Other 3 7%
Student > Bachelor 3 7%
Other 4 10%
Unknown 13 32%
Readers by discipline Count As %
Medicine and Dentistry 9 22%
Chemistry 4 10%
Nursing and Health Professions 3 7%
Psychology 2 5%
Environmental Science 2 5%
Other 7 17%
Unknown 14 34%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 December 2017.
All research outputs
#20,451,228
of 23,007,053 outputs
Outputs from EJNMMI Research
#393
of 564 outputs
Outputs of similar age
#286,215
of 328,360 outputs
Outputs of similar age from EJNMMI Research
#13
of 14 outputs
Altmetric has tracked 23,007,053 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 564 research outputs from this source. They receive a mean Attention Score of 2.5. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 14 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.