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A Serial Analysis of Gene Expression Profile of the Alzheimer’s Disease Tg2576 Mouse Model

Overview of attention for article published in Neurotoxicity Research, September 2009
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A Serial Analysis of Gene Expression Profile of the Alzheimer’s Disease Tg2576 Mouse Model
Published in
Neurotoxicity Research, September 2009
DOI 10.1007/s12640-009-9112-3
Pubmed ID

Amee J. George, Lavinia Gordon, Tim Beissbarth, Irene Koukoulas, R. M. Damian Holsinger, Victoria Perreau, Roberto Cappai, Seong-Seng Tan, Colin L. Masters, Hamish S. Scott, Qiao-Xin Li


Serial analysis of gene expression (SAGE), a technique that allows for the simultaneous detection of expression levels of the entire genome without a priori knowledge of gene sequences, was used to examine the transcriptional expression pattern of the Tg2576 mouse model of Alzheimer's disease (AD). Pairwise comparison between the Tg2576 and nontransgenic SAGE libraries identified a number of differentially expressed genes in the Tg2576 SAGE library, some of which were not previously revealed by the microarray studies. Real-time PCR was used to validate a panel of genes selected from the SAGE analysis in the Tg2576 mouse brain, as well as the hippocampus and temporal cortex of sporadic AD and normal age-matched controls. NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 5 (NDUFA5) and FXYD domain-containing ion transport regulator 6 (FXYD6) were found to be significantly decreased in the Tg2576 mouse brain and AD hippocampus. PTEN-induced putative kinase 1 (PINK1), phosphatidylethanolamine binding protein (PEBP), crystalline mu (CRYM), and neurogranin (NRGN) were significantly decreased in AD tissues. The gene ontologies represented in the Tg2576 data were statistically analyzed and demonstrated a significant under-representation of genes involved with G-protein-coupled receptor signaling and odorant binding, while genes significantly over-represented were focused on cellular communication and cellular physiological processes. The novel approach of profiling the Tg2576 mouse brain using SAGE has identified different genes that could subsequently be examined for their potential as peripheral diagnostic and prognostic markers for Alzheimer's disease.

Mendeley readers

The data shown below were compiled from readership statistics for 36 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Australia 1 3%
United Kingdom 1 3%
Canada 1 3%
Unknown 33 92%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 15 42%
Researcher 10 28%
Professor > Associate Professor 5 14%
Other 2 6%
Student > Bachelor 2 6%
Other 2 6%
Readers by discipline Count As %
Agricultural and Biological Sciences 20 56%
Medicine and Dentistry 7 19%
Biochemistry, Genetics and Molecular Biology 3 8%
Neuroscience 3 8%
Psychology 1 3%
Other 2 6%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 October 2014.
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