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The multifaceted nature of amyloid precursor protein and its proteolytic fragments: friends and foes

Overview of attention for article published in Acta Neuropathologica, October 2014
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (79th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (60th percentile)

Mentioned by

twitter
3 tweeters
patent
1 patent

Citations

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83 Dimensions

Readers on

mendeley
131 Mendeley
Title
The multifaceted nature of amyloid precursor protein and its proteolytic fragments: friends and foes
Published in
Acta Neuropathologica, October 2014
DOI 10.1007/s00401-014-1347-2
Pubmed ID
Authors

Hoang S. Nhan, Karen Chiang, Edward H. Koo

Abstract

The amyloid precursor protein (APP) has occupied a central position in Alzheimer's disease (AD) pathophysiology, in large part due to the seminal role of amyloid-β peptide (Aβ), a proteolytic fragment derived from APP. Although the contribution of Aβ to AD pathogenesis is accepted by many in the research community, recent studies have unveiled a more complicated picture of APP's involvement in neurodegeneration in that other APP-derived fragments have been shown to exert pathological influences on neuronal function. However, not all APP-derived peptides are neurotoxic, and some even harbor neuroprotective effects. In this review, we will explore this complex picture by first discussing the pleiotropic effects of the major APP-derived peptides cleaved by multiple proteases, including soluble APP peptides (sAPPα, sAPPβ), various C- and N-terminal fragments, p3, and APP intracellular domain fragments. In addition, we will highlight two interesting sequences within APP that likely contribute to this duality in APP function. First, it has been found that caspase-mediated cleavage of APP in the cytosolic region may release a cytotoxic peptide, C31, which plays a role in synapse loss and neuronal death. Second, recent studies have implicated the -YENPTY- motif in the cytoplasmic region as a domain that modulates several APP activities through phosphorylation and dephosphorylation of the first tyrosine residue. Thus, this review summarizes the current understanding of various APP proteolytic products and the interplay among them to gain deeper insights into the possible mechanisms underlying neurodegeneration and AD pathophysiology.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 131 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 1 <1%
South Africa 1 <1%
Japan 1 <1%
United States 1 <1%
Unknown 127 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 39 30%
Student > Bachelor 23 18%
Student > Master 23 18%
Researcher 13 10%
Student > Doctoral Student 11 8%
Other 22 17%
Readers by discipline Count As %
Agricultural and Biological Sciences 31 24%
Biochemistry, Genetics and Molecular Biology 22 17%
Neuroscience 21 16%
Chemistry 14 11%
Medicine and Dentistry 13 10%
Other 30 23%

Attention Score in Context

This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 December 2016.
All research outputs
#3,026,366
of 13,368,960 outputs
Outputs from Acta Neuropathologica
#649
of 1,663 outputs
Outputs of similar age
#43,128
of 214,267 outputs
Outputs of similar age from Acta Neuropathologica
#13
of 33 outputs
Altmetric has tracked 13,368,960 research outputs across all sources so far. Compared to these this one has done well and is in the 77th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,663 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.4. This one has gotten more attention than average, scoring higher than 60% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 214,267 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 79% of its contemporaries.
We're also able to compare this research output to 33 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 60% of its contemporaries.