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Cannabinoid receptor 2 as a novel target for promotion of renal cell carcinoma prognosis and progression

Overview of attention for article published in Journal of Cancer Research & Clinical Oncology, October 2017
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (55th percentile)
  • Good Attention Score compared to outputs of the same age and source (74th percentile)

Mentioned by

twitter
2 tweeters

Citations

dimensions_citation
4 Dimensions

Readers on

mendeley
16 Mendeley
Title
Cannabinoid receptor 2 as a novel target for promotion of renal cell carcinoma prognosis and progression
Published in
Journal of Cancer Research & Clinical Oncology, October 2017
DOI 10.1007/s00432-017-2527-y
Pubmed ID
Authors

Jianfeng Wang, Yunze Xu, Liangsong Zhu, Yun Zou, Wen Kong, Baijun Dong, Jiwei Huang, Yonghui Chen, Wei Xue, Yiran Huang, Jin Zhang

Abstract

Renal cell carcinoma (RCC) is the most common malignancy of urogenital system, and patients with RCC may face a poor prognosis. However, limited curable therapeutic options are currently available. The aim of this study is to investigate the role of Cannabinoid receptor 2 (CB2) in RCC progression. Immunohistochemistry was to investigate the expression pattern of CB2 in 418 RCC tissues and explore its prognostic function in RCC patients. Furthermore, the role of used CB2 si-RNA knockdown and inhibited by AM630, a CB2 inverse agonist, on cell proliferation, migration, and cell cycle of RCC cell lines in vitro was also investigated. We observed that CB2 was up-regulated in RCC tissues, and presented as an independent prognostic factor for overall survival of RCC patients and higher CB2 expression tends to have poor clinical outcomes in survival analyses. Moreover, we also observed that CB2, incorporated with pN stage, pathological grade, and recurrence or distant metastasis after surgery, could obviously enhance their prognostic accuracy in a predictive nomogram analysis. In addition, knockdown or inhibition by AM630 for the expression of CB2 in vitro could significantly decreased cell proliferation and migration, and obviously induced cell cycle arrest in G2/M of RCC cells. CB2 expression is functionally related to cellular proliferation, migration, and cell cycle of RCC cells. Our data suggest that CB2 might be a potential therapeutic target for RCC.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 16 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 16 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 3 19%
Researcher 3 19%
Unspecified 2 13%
Student > Ph. D. Student 2 13%
Student > Postgraduate 1 6%
Other 5 31%
Readers by discipline Count As %
Agricultural and Biological Sciences 4 25%
Unspecified 4 25%
Biochemistry, Genetics and Molecular Biology 2 13%
Medicine and Dentistry 2 13%
Pharmacology, Toxicology and Pharmaceutical Science 1 6%
Other 3 19%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 January 2018.
All research outputs
#6,693,913
of 12,347,102 outputs
Outputs from Journal of Cancer Research & Clinical Oncology
#735
of 1,220 outputs
Outputs of similar age
#117,549
of 276,058 outputs
Outputs of similar age from Journal of Cancer Research & Clinical Oncology
#11
of 50 outputs
Altmetric has tracked 12,347,102 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,220 research outputs from this source. They receive a mean Attention Score of 3.0. This one is in the 39th percentile – i.e., 39% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 276,058 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 55% of its contemporaries.
We're also able to compare this research output to 50 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 74% of its contemporaries.