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Harmonization of Neuroticism and Extraversion phenotypes across inventories and cohorts in the Genetics of Personality Consortium: an application of Item Response Theory

Overview of attention for article published in Behavior Genetics, May 2014
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Title
Harmonization of Neuroticism and Extraversion phenotypes across inventories and cohorts in the Genetics of Personality Consortium: an application of Item Response Theory
Published in
Behavior Genetics, May 2014
DOI 10.1007/s10519-014-9654-x
Pubmed ID
Authors

Stéphanie M. van den Berg, Marleen H. M. de Moor, Matt McGue, Erik Pettersson, Antonio Terracciano, Karin J. H. Verweij, Najaf Amin, Jaime Derringer, Tõnu Esko, Gerard van Grootheest, Narelle K. Hansell, Jennifer Huffman, Bettina Konte, Jari Lahti, Michelle Luciano, Lindsay K. Matteson, Alexander Viktorin, Jasper Wouda, Arpana Agrawal, Jüri Allik, Laura Bierut, Ulla Broms, Harry Campbell, George Davey Smith, Johan G. Eriksson, Luigi Ferrucci, Barbera Franke, Jean-Paul Fox, Eco J. C. de Geus, Ina Giegling, Alan J. Gow, Richard Grucza, Annette M. Hartmann, Andrew C. Heath, Kauko Heikkilä, William G. Iacono, Joost Janzing, Markus Jokela, Lambertus Kiemeney, Terho Lehtimäki, Pamela A. F. Madden, Patrik K. E. Magnusson, Kate Northstone, Teresa Nutile, Klaasjan G. Ouwens, Aarno Palotie, Alison Pattie, Anu-Katriina Pesonen, Ozren Polasek, Lea Pulkkinen, Laura Pulkki-Råback, Olli T. Raitakari, Anu Realo, Richard J. Rose, Daniela Ruggiero, Ilkka Seppälä, Wendy S. Slutske, David C. Smyth, Rossella Sorice, John M. Starr, Angelina R. Sutin, Toshiko Tanaka, Josine Verhagen, Sita Vermeulen, Eero Vuoksimaa, Elisabeth Widen, Gonneke Willemsen, Margaret J. Wright, Lina Zgaga, Dan Rujescu, Andres Metspalu, James F. Wilson, Marina Ciullo, Caroline Hayward, Igor Rudan, Ian J. Deary, Katri Räikkönen, Alejandro Arias Vasquez, Paul T. Costa, Liisa Keltikangas-Järvinen, Cornelia M. van Duijn, Brenda W. J. H. Penninx, Robert F. Krueger, David M. Evans, Jaakko Kaprio, Nancy L. Pedersen, Nicholas G. Martin, Dorret I. Boomsma

Abstract

Mega- or meta-analytic studies (e.g. genome-wide association studies) are increasingly used in behavior genetics. An issue in such studies is that phenotypes are often measured by different instruments across study cohorts, requiring harmonization of measures so that more powerful fixed effect meta-analyses can be employed. Within the Genetics of Personality Consortium, we demonstrate for two clinically relevant personality traits, Neuroticism and Extraversion, how Item-Response Theory (IRT) can be applied to map item data from different inventories to the same underlying constructs. Personality item data were analyzed in >160,000 individuals from 23 cohorts across Europe, USA and Australia in which Neuroticism and Extraversion were assessed by nine different personality inventories. Results showed that harmonization was very successful for most personality inventories and moderately successful for some. Neuroticism and Extraversion inventories were largely measurement invariant across cohorts, in particular when comparing cohorts from countries where the same language is spoken. The IRT-based scores for Neuroticism and Extraversion were heritable (48 and 49 %, respectively, based on a meta-analysis of six twin cohorts, total N = 29,496 and 29,501 twin pairs, respectively) with a significant part of the heritability due to non-additive genetic factors. For Extraversion, these genetic factors qualitatively differ across sexes. We showed that our IRT method can lead to a large increase in sample size and therefore statistical power. The IRT approach may be applied to any mega- or meta-analytic study in which item-based behavioral measures need to be harmonized.

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Geographical breakdown

Country Count As %
Finland 2 1%
Spain 1 <1%
United States 1 <1%
Denmark 1 <1%
Unknown 182 97%

Demographic breakdown

Readers by professional status Count As %
Researcher 37 20%
Student > Ph. D. Student 31 17%
Student > Bachelor 27 14%
Student > Master 14 7%
Student > Doctoral Student 11 6%
Other 29 16%
Unknown 38 20%
Readers by discipline Count As %
Psychology 48 26%
Medicine and Dentistry 22 12%
Biochemistry, Genetics and Molecular Biology 16 9%
Agricultural and Biological Sciences 14 7%
Neuroscience 11 6%
Other 26 14%
Unknown 50 27%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 September 2014.
All research outputs
#15,274,524
of 22,714,025 outputs
Outputs from Behavior Genetics
#645
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Outputs of similar age
#133,444
of 226,895 outputs
Outputs of similar age from Behavior Genetics
#5
of 6 outputs
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