Title |
Inhibitory effects of miR-146b-5p on cell migration and invasion of pancreatic cancer by targeting MMP16
|
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Published in |
Current Medical Science, August 2011
|
DOI | 10.1007/s11596-011-0481-5 |
Pubmed ID | |
Authors |
Fan Lin, Xin Wang, Zhigang Jie, Xiaoquan Hong, Xu Li, Min Wang, Yahong Yu |
Abstract |
Previous studies have shown that miRNAs participate in a wide range of biological functions and play important roles in various human diseases including cancer. We found miR-146b-5p significantly dysregulated in human pancreatic cancer cells by qRT-PCR. To demonstrate its function and regulation mechanism, we overexpressed miR-146-5p by transfecting the mimics. Our data showed that miR-146b-5p overexpression significantly reduced the abilities of migration and invasion of MIA PaCa-2 pancreatic cancer cells. Furthermore, we found that matrix metalloproteinase 16 (MMP16) was a downstream target of miR-146b-5p by dual-luciferase reporter assay. Altogether, our findings suggest that miR-146b-5p may be involved in pancreatic cancer cell migration and invasion by targeting MMP16, and miR-146b-5p may be a potential therapeutic target for the pancreatic cancer. |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
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United States | 1 | 4% |
Unknown | 25 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 7 | 27% |
Researcher | 6 | 23% |
Student > Master | 3 | 12% |
Student > Bachelor | 2 | 8% |
Professor | 1 | 4% |
Other | 2 | 8% |
Unknown | 5 | 19% |
Readers by discipline | Count | As % |
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Pharmacology, Toxicology and Pharmaceutical Science | 1 | 4% |
Neuroscience | 1 | 4% |
Other | 1 | 4% |
Unknown | 6 | 23% |