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Coupling of translation initiation and termination does not depend on the mode of initiation

Overview of attention for article published in Biochemistry (00062979), July 2017
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Title
Coupling of translation initiation and termination does not depend on the mode of initiation
Published in
Biochemistry (00062979), July 2017
DOI 10.1134/s0006297917070069
Pubmed ID
Authors

E. A. Sogorin, G. K. Selikhanov, S. Ch. Agalarov

Abstract

Recently we described a novel phenomenon observed during eukaryotic translation in a cell-free system: the coupling of initiation and termination on different mRNA molecules. Here we show that the phenomenon does not depend on a special mode of initiation. The mRNAs with certain leader sequences known to require different determinants for successful initiation were examined. Even in a case of using the intergenic internal ribosome entry site (IRES) of cricket paralysis virus RNA as the leader sequence, while no initiation factors are required, the effect of coupling is well expressed, including trials in the presence of hippuristanol as an inhibitor of eIF4A. Thus, the effect persists in the absence of scanning and does not depend on initiator tRNA and eIF2. The results suggest that the initiation factors are not involved in the coupling mechanism.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 8 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 8 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 3 38%
Student > Ph. D. Student 2 25%
Unspecified 1 13%
Unknown 2 25%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 3 38%
Agricultural and Biological Sciences 2 25%
Unspecified 1 13%
Unknown 2 25%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 September 2017.
All research outputs
#9,459,651
of 11,841,124 outputs
Outputs from Biochemistry (00062979)
#17,510
of 18,730 outputs
Outputs of similar age
#196,594
of 267,979 outputs
Outputs of similar age from Biochemistry (00062979)
#115
of 141 outputs
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