Title |
Microbiome Diversity and Asthma and Allergy Risk
|
---|---|
Published in |
Current Allergy and Asthma Reports, August 2014
|
DOI | 10.1007/s11882-014-0466-0 |
Pubmed ID | |
Authors |
Antje Legatzki, Barbara Rösler, Erika von Mutius |
Abstract |
The prevalence of asthma and allergy has been constantly increasing in Westernized countries in the last decades. Asthma and allergies are complex diseases with a local tissue inflammation that are determined by genetic and environmental factors. Because the commensal microflora is crucial to maintain inflammatory homeostasis and to induce immune regulation, the microbiome may play an important role for the development of allergic conditions. New techniques such as next-generation sequencing methods give the opportunity to explore the microbial community structure of the human body comprehensively. In this review, we will discuss the available literature concerning the human microbiota and asthma and allergy development and occurrence. The focus is on studies of the local microbiome of the place of inflammation, the gastrointestinal microbiome, and the influence of intrinsic factors relating to the host and extrinsic factors relating to the external environment on the microbiome. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 14% |
Unknown | 6 | 86% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 7 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Colombia | 1 | <1% |
Germany | 1 | <1% |
Korea, Republic of | 1 | <1% |
Denmark | 1 | <1% |
Thailand | 1 | <1% |
Unknown | 155 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 25 | 16% |
Researcher | 24 | 15% |
Student > Bachelor | 22 | 14% |
Student > Ph. D. Student | 19 | 12% |
Other | 11 | 7% |
Other | 31 | 19% |
Unknown | 28 | 18% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 43 | 27% |
Agricultural and Biological Sciences | 32 | 20% |
Immunology and Microbiology | 17 | 11% |
Biochemistry, Genetics and Molecular Biology | 13 | 8% |
Nursing and Health Professions | 9 | 6% |
Other | 15 | 9% |
Unknown | 31 | 19% |