↓ Skip to main content

Microscale Bioadhesive Hydrogel Arrays for Cell Engineering Applications

Overview of attention for article published in Cellular and Molecular Bioengineering, August 2014
Altmetric Badge

About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#27 of 280)
  • High Attention Score compared to outputs of the same age (81st percentile)
  • High Attention Score compared to outputs of the same age and source (95th percentile)

Mentioned by

twitter
10 tweeters
facebook
1 Facebook page

Citations

dimensions_citation
21 Dimensions

Readers on

mendeley
45 Mendeley
Title
Microscale Bioadhesive Hydrogel Arrays for Cell Engineering Applications
Published in
Cellular and Molecular Bioengineering, August 2014
DOI 10.1007/s12195-014-0353-8
Pubmed ID
Authors

Ravi Ghanshyam Patel, Alberto Purwada, Leandro Cerchietti, Giorgio Inghirami, Ari Melnick, Akhilesh K. Gaharwar, Ankur Singh

Abstract

Bioengineered hydrogels have been explored in cell and tissue engineering applications to support cell growth and modulate its behavior. A rationally designed scaffold should allow for encapsulated cells to survive, adhere, proliferate, remodel the niche, and can be used for controlled delivery of biomolecules. Here we report a microarray of composite bioadhesive microgels with modular dimensions, tunable mechanical properties and bulk modified adhesive biomolecule composition. Composite bioadhesive microgels of maleimide functionalized polyethylene glycol (PEG-MAL) with interpenetrating network (IPN) of gelatin ionically cross-linked with silicate nanoparticles were engineered by integrating microfabrication with Michael-type addition chemistry and ionic gelation. By encapsulating clinically relevant anchorage-dependent cervical cancer cells and suspension leukemia cells as cell culture models in these composite microgels, we demonstrate enhanced cell spreading, survival, and metabolic activity compared to control gels. The composite bioadhesive hydrogels represent a platform that could be used to study independent effect of stiffness and adhesive ligand density on cell survival and function. We envision that such microarrays of cell adhesive microenvironments, which do not require harsh chemical and UV crosslinking conditions, will provide a more efficacious cell culture platform that can be used to study cell behavior and survival, function as building blocks to fabricate 3D tissue structures, cell delivery systems, and high throughput drug screening devices.

Twitter Demographics

The data shown below were collected from the profiles of 10 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 45 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 2%
Switzerland 1 2%
Unknown 43 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 12 27%
Researcher 7 16%
Unspecified 5 11%
Student > Master 5 11%
Student > Bachelor 4 9%
Other 12 27%
Readers by discipline Count As %
Engineering 10 22%
Agricultural and Biological Sciences 7 16%
Unspecified 7 16%
Materials Science 6 13%
Chemistry 4 9%
Other 11 24%

Attention Score in Context

This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 August 2014.
All research outputs
#2,330,836
of 13,038,232 outputs
Outputs from Cellular and Molecular Bioengineering
#27
of 280 outputs
Outputs of similar age
#35,798
of 193,425 outputs
Outputs of similar age from Cellular and Molecular Bioengineering
#1
of 21 outputs
Altmetric has tracked 13,038,232 research outputs across all sources so far. Compared to these this one has done well and is in the 82nd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 280 research outputs from this source. They receive a mean Attention Score of 2.5. This one has done particularly well, scoring higher than 90% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 193,425 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 81% of its contemporaries.
We're also able to compare this research output to 21 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 95% of its contemporaries.