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Cysteine S-conjugate β-lyases

Overview of attention for article published in Amino Acids, February 2006
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (67th percentile)
  • Good Attention Score compared to outputs of the same age and source (66th percentile)

Mentioned by

patent
1 patent

Citations

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60 Dimensions

Readers on

mendeley
28 Mendeley
Title
Cysteine S-conjugate β-lyases
Published in
Amino Acids, February 2006
DOI 10.1007/s00726-005-0243-4
Pubmed ID
Authors

A. J. L. Cooper, J. T. Pinto

Abstract

Cysteine S-conjugate beta-lyases are pyridoxal 5'-phosphate-containing enzymes that catalyze beta-elimination reactions with cysteine S-conjugates that possess an electron-withdrawing group attached at the sulfur. The end products of the beta-lyase reaction are pyruvate, ammonium and a sulfur-containing fragment. If the sulfur-containing fragment is reactive, the parent cysteine S-conjugate may be toxic, particularly to kidney mitochondria. Halogenated alkenes are examples of electrophiles that are bioactivated (toxified) by conversion to cysteine S-conjugates. These conjugates are converted by cysteine S-conjugate beta-lyases to thioacylating fragments. Several cysteine S-conjugates found in allium foods (garlic and onion) are beta-lyase substrates. This finding may account in part for the chemopreventive activity of allium products. This review (1) identifies enzymes that catalyze cysteine S-conjugate beta-lyase reactions, (2) suggests that toxicant channeling may contribute to halogenated cysteine S-conjugate-induced toxicity to mitochondria, and (3) proposes mechanisms that may contribute to the antiproliferative effects of sulfur-containing fragments eliminated from allium-derived cysteine S-conjugates.

Mendeley readers

The data shown below were compiled from readership statistics for 28 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Belgium 2 7%
Australia 1 4%
Czechia 1 4%
Unknown 24 86%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 9 32%
Student > Bachelor 5 18%
Other 3 11%
Professor 3 11%
Unspecified 3 11%
Other 5 18%
Readers by discipline Count As %
Agricultural and Biological Sciences 8 29%
Unspecified 6 21%
Pharmacology, Toxicology and Pharmaceutical Science 5 18%
Biochemistry, Genetics and Molecular Biology 3 11%
Engineering 2 7%
Other 4 14%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 August 2007.
All research outputs
#3,071,832
of 11,238,417 outputs
Outputs from Amino Acids
#259
of 933 outputs
Outputs of similar age
#52,816
of 188,054 outputs
Outputs of similar age from Amino Acids
#5
of 18 outputs
Altmetric has tracked 11,238,417 research outputs across all sources so far. This one has received more attention than most of these and is in the 50th percentile.
So far Altmetric has tracked 933 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.9. This one is in the 45th percentile – i.e., 45% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 188,054 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 67% of its contemporaries.
We're also able to compare this research output to 18 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 66% of its contemporaries.