| Title |
Thymidylate Synthase as a Prognostic Biomarker for Locally Advanced Rectal Cancer after multimodal Treatment
|
|---|---|
| Published in |
Annals of Surgical Oncology, February 2011
|
| DOI | 10.1245/s10434-011-1608-4 |
| Pubmed ID | |
| Authors |
Lena-Christin Conradi, Annalen Bleckmann, Markus Schirmer, Thilo Sprenger, Peter Jo, Kia Homayounfar, Hendrik A. Wolff, Hilka Rothe, Peter Middel, Heinz Becker, Michael B. Ghadimi, Tim Beissbarth, Torsten Liersch |
| Abstract |
For years, 5-fluorouracil (5-FU) has been the backbone of radiochemotherapy (RCT) of locally advanced rectal cancer. Its main target, thymidylate synthase (TS), is speculated to be an important biomarker for response prediction and long-term prognosis. In this study, we analyzed TS expression in the rectal cancer tissue of 208 patients to evaluate its predictive/prognostic potential. |
Mendeley readers
The data shown below were compiled from readership statistics for 54 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Hong Kong | 1 | 2% |
| Spain | 1 | 2% |
| Ukraine | 1 | 2% |
| Unknown | 51 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 11 | 20% |
| Researcher | 10 | 19% |
| Student > Master | 9 | 17% |
| Student > Bachelor | 4 | 7% |
| Other | 4 | 7% |
| Other | 5 | 9% |
| Unknown | 11 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 27 | 50% |
| Biochemistry, Genetics and Molecular Biology | 4 | 7% |
| Agricultural and Biological Sciences | 4 | 7% |
| Computer Science | 2 | 4% |
| Nursing and Health Professions | 2 | 4% |
| Other | 3 | 6% |
| Unknown | 12 | 22% |