Physiological impact of cell senescence in vivo: Limiting Tissue Damage
Ageing Research,
In addition to their tumor suppression function, senescent cells also play a beneficial role in non-cancer pathologyby limiting…
In addition to their tumor suppression function, senescent cells also play a beneficial role in non-cancer pathologyby limiting…
While the history of research on cell senescence counts for more than half a century, only in the last 10 years the functional…
When cells become senescent in vitro they often become resistant to apoptotic stimuli in comparison to proliferating cells. It…
In addition to providing a protective role in tumour suppression and tissue damage, senescent cells may also function in…
The persistence and accumulation of senescent cells has been shown to potentially play a role in the pathophysiology of ageing…
The presence of DNA damage and subsequent up-regulation of p16(INK4a) in quiescent cells in vivo may induce a pre-senescent…
Taken from: Physiological and Pathological Consequences of Cellular SenescenceThe ability of senescent cells to trigger an…
The standard SA-beta-gal staining, while indicative of the presence of senescent cells, is not an absolute marker …
AbstractCellular senescence, a permanent state of cell cycle arrest accompanied by a complex phenotype, is an essential…