Title |
Could 18 F-DPA-714 PET imaging be interesting to use in the early post-stroke period?
|
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Published in |
EJNMMI Research, June 2014
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DOI | 10.1186/s13550-014-0028-4 |
Pubmed ID | |
Authors |
Maria-Joao Ribeiro, Johnny Vercouillie, Severine Debiais, Jean-Philippe Cottier, Isabelle Bonnaud, Vincent Camus, Samuel Banister, Michael Kassiou, Nicolas Arlicot, Denis Guilloteau |
Abstract |
Cerebral stroke is a severe and frequent condition that requires rapid and reliable diagnosis. If administered shortly after the first symptoms manifest themselves, IV thrombolysis has been shown to increase the functional prognosis by restoring brain reperfusion. However, a better understanding of the pathophysiology of stroke should help to identify potential new therapeutic targets. Stroke is known to induce an inflammatory brain reaction that involves overexpression of the 18-kDa translocator protein (TSPO) in glial cells and infiltrated leukocytes, which can be visualised by positron emission tomography (PET). We aimed to evaluate post-stroke neuroinflammation using the PET TSPO radioligand (18) F-DPA-714. |
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