Title |
CARs in Chronic Lymphocytic Leukemia – Ready to Drive
|
---|---|
Published in |
Current Hematologic Malignancy Reports, December 2012
|
DOI | 10.1007/s11899-012-0145-y |
Pubmed ID | |
Authors |
Chitra Hosing, Partow Kebriaei, William Wierda, Bipulendu Jena, Laurence J. N. Cooper, Elizabeth Shpall |
Abstract |
Adoptive transfer of antigen-specific T cells has been adapted by investigators for treatment of chronic lymphocytic leukemia (CLL). To overcome issues of immune tolerance which limits the endogenous adaptive immune response to tumor-associated antigens (TAAs), robust systems for the genetic modification and characterization of T cells expressing chimeric antigen receptors (CARs) to redirect specificity have been produced. Refinements with regards to persistence and trafficking of the genetically modified T cells are underway to help improve potency. Clinical trials utilizing this technology demonstrate feasibility, and increasingly, these early-phase trials are demonstrating impressive anti-tumor effects, particularly for CLL patients, paving the way for multi-center trials to establish the efficacy of CAR(+) T cell therapy. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 2% |
Unknown | 44 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 12 | 27% |
Researcher | 9 | 20% |
Student > Bachelor | 5 | 11% |
Professor > Associate Professor | 3 | 7% |
Student > Master | 3 | 7% |
Other | 5 | 11% |
Unknown | 8 | 18% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 14 | 31% |
Agricultural and Biological Sciences | 12 | 27% |
Biochemistry, Genetics and Molecular Biology | 3 | 7% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 2% |
Immunology and Microbiology | 1 | 2% |
Other | 3 | 7% |
Unknown | 11 | 24% |