Evidence That Loss-of-Function Filaggrin Gene Mutations Evolved in Northern Europeans to Favor Intracutaneous Vitamin D3 Production

This led to the very logical hypothesis that this specific mutation was selected for in populations living in northern latitudes where decreased sun exposure impairs vitD production However the downside of reduced FLG production is reduced skin integrity

Loss-of-function filaggrin gene mutation to increase cutaneous vitamin D3 production? This explains a lot https://t.co/cUX803O8Fp

Loss-of-Function Filaggrin Gene Mutations Evolved in Northern Europeans to Favor Intracutaneous Vitamin D3 Production http://t.co/1tR0nnLd8p