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Gut microbiota and physiologic bowel 18F-FDG uptake

Overview of attention for article published in EJNMMI Research, August 2017
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Mentioned by

twitter
3 tweeters

Citations

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6 Dimensions

Readers on

mendeley
37 Mendeley
citeulike
1 CiteULike
Title
Gut microbiota and physiologic bowel 18F-FDG uptake
Published in
EJNMMI Research, August 2017
DOI 10.1186/s13550-017-0318-8
Pubmed ID
Authors

Ji Yeon Kang, Han-Na Kim, Yoosoo Chang, Yeojun Yun, Seungho Ryu, Hocheol Shin, Hyung-Lae Kim, Kang, Ji Yeon, Kim, Han-Na, Chang, Yoosoo, Yun, Yeojun, Ryu, Seungho, Shin, Hocheol, Kim, Hyung-Lae

Abstract

We investigated the association between physiologic bowel FDG uptake and gut microbiota. FDG uptake in the normal large and small intestine is widely variable both in distribution and intensity. The etiology of physiologic bowel (18)F-FDG activity remains unknown. We included 63 healthy male subjects. After overnight fasting, blood samples and (18)F-FDG PET/CT scans were taken. Fecal samples were collected, and gut microbiota were analyzed by 16S rRNA gene-pyrosequencing. The physiologic bowel FDG uptake was classified into three groups by visual assessment and measured using the maximum and mean standardized uptake value. We used the total bowel to liver uptake ratio (TBRmax and TBRmean). There was no significant difference in age, BMI, or lipid profiles between groups. To identify specific microbial taxa associated with the bowel FDG uptake while accounting for age and BMI, we performed a generalized linear model. At the genus level, the group with focal or intense FDG uptake in the intestine was associated with low abundance of unclassified Clostridiales. The group with intestinal FDG uptake lower than the liver was associated with high abundance of Klebsiella. TBRmax and TBRmean were negatively associated with abundance of unclassified Enterobacteriaceae. We cautiously speculate that physiologic bowel FDG activity might be caused by an increase in intestinal permeability and may reflect an impaired barrier function in the intestine.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 37 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 37 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 8 22%
Researcher 7 19%
Other 5 14%
Professor > Associate Professor 4 11%
Student > Master 3 8%
Other 3 8%
Unknown 7 19%
Readers by discipline Count As %
Medicine and Dentistry 13 35%
Immunology and Microbiology 4 11%
Biochemistry, Genetics and Molecular Biology 4 11%
Psychology 2 5%
Nursing and Health Professions 1 3%
Other 4 11%
Unknown 9 24%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 September 2017.
All research outputs
#6,690,375
of 11,691,744 outputs
Outputs from EJNMMI Research
#58
of 224 outputs
Outputs of similar age
#127,087
of 263,836 outputs
Outputs of similar age from EJNMMI Research
#1
of 7 outputs
Altmetric has tracked 11,691,744 research outputs across all sources so far. This one is in the 40th percentile – i.e., 40% of other outputs scored the same or lower than it.
So far Altmetric has tracked 224 research outputs from this source. They receive a mean Attention Score of 1.8. This one has gotten more attention than average, scoring higher than 71% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 263,836 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 48th percentile – i.e., 48% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 7 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them