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Republished study: long-term toxicity of a Roundup herbicide and a Roundup-tolerantgenetically modified maize

Overview of attention for article published in Environmental Sciences Europe, June 2014
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • One of the highest-scoring outputs from this source (#1 of 346)
  • High Attention Score compared to outputs of the same age (99th percentile)

Citations

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127 Dimensions

Readers on

mendeley
639 Mendeley
Title
Republished study: long-term toxicity of a Roundup herbicide and a Roundup-tolerantgenetically modified maize
Published in
Environmental Sciences Europe, June 2014
DOI 10.1186/s12302-014-0014-5
Pubmed ID
Authors

Gilles-Eric Séralini, Emilie Clair, Robin Mesnage, Steeve Gress, Nicolas Defarge, Manuela Malatesta, Didier Hennequin, Joël Spiroux de Vendômois

Abstract

The health effects of a Roundup-tolerant NK603 genetically modified (GM) maize (from 11% in the diet), cultivated with or without Roundup application and Roundup alone (from 0.1 ppb of the full pesticide containing glyphosate and adjuvants) in drinking water, were evaluated for 2 years in rats. This study constitutes a follow-up investigation of a 90-day feeding study conducted by Monsanto in order to obtain commercial release of this GMO, employing the same rat strain and analyzing biochemical parameters on the same number of animals per group as our investigation. Our research represents the first chronic study on these substances, in which all observations including tumors are reported chronologically. Thus, it was not designed as a carcinogenicity study. We report the major findings with 34 organs observed and 56 parameters analyzed at 11 time points for most organs. Biochemical analyses confirmed very significant chronic kidney deficiencies, for all treatments and both sexes; 76% of the altered parameters were kidney-related. In treated males, liver congestions and necrosis were 2.5 to 5.5 times higher. Marked and severe nephropathies were also generally 1.3 to 2.3 times greater. In females, all treatment groups showed a two- to threefold increase in mortality, and deaths were earlier. This difference was also evident in three male groups fed with GM maize. All results were hormone- and sex-dependent, and the pathological profiles were comparable. Females developed large mammary tumors more frequently and before controls; the pituitary was the second most disabled organ; the sex hormonal balance was modified by consumption of GM maize and Roundup treatments. Males presented up to four times more large palpable tumors starting 600 days earlier than in the control group, in which only one tumor was noted. These results may be explained by not only the non-linear endocrine-disrupting effects of Roundup but also by the overexpression of the EPSPS transgene or other mutational effects in the GM maize and their metabolic consequences. Our findings imply that long-term (2 year) feeding trials need to be conducted to thoroughly evaluate the safety of GM foods and pesticides in their full commercial formulations.

Twitter Demographics

The data shown below were collected from the profiles of 3,277 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 639 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 9 1%
France 4 <1%
Argentina 3 <1%
Germany 3 <1%
Belgium 2 <1%
Italy 2 <1%
Spain 2 <1%
Mexico 2 <1%
Brazil 2 <1%
Other 14 2%
Unknown 596 93%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 127 20%
Student > Master 107 17%
Researcher 103 16%
Student > Ph. D. Student 79 12%
Other 36 6%
Other 125 20%
Unknown 62 10%
Readers by discipline Count As %
Agricultural and Biological Sciences 248 39%
Medicine and Dentistry 62 10%
Environmental Science 51 8%
Biochemistry, Genetics and Molecular Biology 49 8%
Chemistry 20 3%
Other 127 20%
Unknown 82 13%

Attention Score in Context

This research output has an Altmetric Attention Score of 2531. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 July 2020.
All research outputs
#924
of 15,574,460 outputs
Outputs from Environmental Sciences Europe
#1
of 346 outputs
Outputs of similar age
#8
of 189,993 outputs
Outputs of similar age from Environmental Sciences Europe
#1
of 1 outputs
Altmetric has tracked 15,574,460 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 346 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 19.8. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 189,993 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them