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Niclosamide piperazine prevents high-fat diet-induced obesity and diabetic symptoms in mice

Overview of attention for article published in Eating and Weight Disorders: Studies on Anorexia, Bulimia and Obesity, August 2017
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Title
Niclosamide piperazine prevents high-fat diet-induced obesity and diabetic symptoms in mice
Published in
Eating and Weight Disorders: Studies on Anorexia, Bulimia and Obesity, August 2017
DOI 10.1007/s40519-017-0424-7
Pubmed ID
Authors

Jingjing Guo, Hanlin Tao, Amer Alasadi, Qingrong Huang, Shengkan Jin

Abstract

Obesity and type 2 diabetes (T2D) have become the major public health challenges globally. Mitochondrial uncoupling, which reduces intracellular lipid loads and corrects the underlying cause of insulin resistance, has emerged as a promising anti-obese and anti-diabetic intervention. Niclosamide is an anthelmintic drug approved by the US FDA with the mechanism of action that uncouples mitochondria of parasitic worms. Recently, niclosamide ethanolamine salt (NEN) was found to be a safe and effective hepatic mitochondrial uncoupler for the prevention and treatment of obesity and T2D in mouse models. The striking features of NEN prompt us to examine the anti-obese and anti-diabetic efficacy of other salt forms of niclosamide, with the ultimate goal to identify a suitable salt formulation for future clinical development. Here, we report the study with niclosamide piperazine salt (NPP), another salt form of niclosamide with documented safety profile. Mitochondrial uncoupling activity of NEN and NPP were determined by oxygen consumption assay with Seahorse XF24e Analyzer, as well as by mitochondrial membrane potential measurement in cultured cells. The in vivo anti-diabetic and anti-obesity activities were determined in C57BL/6J mice fed high-fat diet (HFD) or HFD containing 2000 ppm. NPP for 11 weeks. Niclosamide piperazine salt showed a comparable mitochondrial uncoupling activity to NEN. Oral administration of NPP significantly reduced HFD-induced obesity, hyperglycemia and hepatic steatosis, and sensitized the insulin responses in mice. Niclosamide piperazine salt may hold the promise to become an alternative to NEN as a drug lead for the treatment of obesity and T2D. No level of evidence Animal study.

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Mendeley readers

The data shown below were compiled from readership statistics for 6 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 6 100%

Demographic breakdown

Readers by professional status Count As %
Unspecified 3 50%
Student > Master 1 17%
Researcher 1 17%
Student > Bachelor 1 17%
Readers by discipline Count As %
Unspecified 3 50%
Medicine and Dentistry 2 33%
Chemistry 1 17%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 August 2017.
All research outputs
#11,165,836
of 12,550,439 outputs
Outputs from Eating and Weight Disorders: Studies on Anorexia, Bulimia and Obesity
#411
of 489 outputs
Outputs of similar age
#225,520
of 264,354 outputs
Outputs of similar age from Eating and Weight Disorders: Studies on Anorexia, Bulimia and Obesity
#18
of 21 outputs
Altmetric has tracked 12,550,439 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
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