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Dietary gluten and the development of type 1 diabetes

Overview of attention for article published in Diabetologia, May 2014
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (98th percentile)
  • High Attention Score compared to outputs of the same age and source (88th percentile)

Mentioned by

5 news outlets
85 tweeters
15 Facebook pages
1 Wikipedia page
1 Redditor


38 Dimensions

Readers on

117 Mendeley
Dietary gluten and the development of type 1 diabetes
Published in
Diabetologia, May 2014
DOI 10.1007/s00125-014-3265-1
Pubmed ID

Julie C. Antvorskov, Knud Josefsen, Kåre Engkilde, David P. Funda, Karsten Buschard


Gluten proteins differ from other cereal proteins as they are partly resistant to enzymatic processing in the intestine, resulting in a continuous exposure of the proteins to the intestinal immune system. In addition to being a disease-initiating factor in coeliac disease (CD), gluten intake might affect type 1 diabetes development. Studies in animal models of type 1 diabetes have documented that the pathogenesis is influenced by diet. Thus, a gluten-free diet largely prevents diabetes in NOD mice while a cereal-based diet promotes diabetes development. In infants, amount, timing and mode of introduction have been shown to affect the diabetogenic potential of gluten, and some studies now suggest that a gluten-free diet may preserve beta cell function. Other studies have not found this effect. There is evidence that the intestinal immune system plays a primary role in the pathogenesis of type 1 diabetes, as diabetogenic T cells are initially primed in the gut, islet-infiltrating T cells express gut-associated homing receptors, and mesenteric lymphocytes transfer diabetes from NOD mice to NOD/severe combined immunodeficiency (SCID) mice. Thus, gluten may affect diabetes development by influencing proportional changes in immune cell populations or by modifying the cytokine/chemokine pattern towards an inflammatory profile. This supports an important role for gluten intake in the pathogenesis of type 1 diabetes and further studies should be initiated to clarify whether a gluten-free diet could prevent disease in susceptible individuals or be used with newly diagnosed patients to stop disease progression.

Twitter Demographics

The data shown below were collected from the profiles of 85 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 117 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 <1%
Germany 1 <1%
Mexico 1 <1%
Netherlands 1 <1%
Unknown 113 97%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 36 31%
Student > Master 26 22%
Student > Ph. D. Student 11 9%
Student > Doctoral Student 11 9%
Researcher 11 9%
Other 22 19%
Readers by discipline Count As %
Medicine and Dentistry 51 44%
Agricultural and Biological Sciences 22 19%
Biochemistry, Genetics and Molecular Biology 14 12%
Nursing and Health Professions 7 6%
Social Sciences 4 3%
Other 19 16%

Attention Score in Context

This research output has an Altmetric Attention Score of 102. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 August 2018.
All research outputs
of 13,384,293 outputs
Outputs from Diabetologia
of 3,858 outputs
Outputs of similar age
of 188,310 outputs
Outputs of similar age from Diabetologia
of 45 outputs
Altmetric has tracked 13,384,293 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,858 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 16.8. This one has done particularly well, scoring higher than 96% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 188,310 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 45 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 88% of its contemporaries.