@AlanBOCallaghan Its effectively a "soft" version of the inappropriate background problem. Some genes are unlikely to ever be called DE since they are shorter than others (like genes that are not expressed shouldn't be in the background). See https://t.co
RT @StevenXGe: Wow. Twitter is an awesome place to learn! I wrote a random thought and instantly got feedback from experts. The GOSeq pack…
RT @StevenXGe: Wow. Twitter is an awesome place to learn! I wrote a random thought and instantly got feedback from experts. The GOSeq pack…
Wow. Twitter is an awesome place to learn! I wrote a random thought and instantly got feedback from experts. The GOSeq package seems to be able to correct biased results towards "long and highly expressed transcripts". https://t.co/0nZqcxPP7G
RT @mike_schatz: Nice talk by John Chamberlin & @aaronquinlan discussing biases in scRNAseq due to intron counting. Recommends methods tha…
RT @mike_schatz: Nice talk by John Chamberlin & @aaronquinlan discussing biases in scRNAseq due to intron counting. Recommends methods tha…
RT @mike_schatz: Nice talk by John Chamberlin & @aaronquinlan discussing biases in scRNAseq due to intron counting. Recommends methods tha…
RT @mike_schatz: Nice talk by John Chamberlin & @aaronquinlan discussing biases in scRNAseq due to intron counting. Recommends methods tha…
RT @mike_schatz: Nice talk by John Chamberlin & @aaronquinlan discussing biases in scRNAseq due to intron counting. Recommends methods tha…
RT @aaronquinlan: Thanks! @jtchamberlin finds that the bias is most pronounced in single nucleus data where there nascent RNA is more abund…
RT @aaronquinlan: Thanks! @jtchamberlin finds that the bias is most pronounced in single nucleus data where there nascent RNA is more abund…
Thanks! @jtchamberlin finds that the bias is most pronounced in single nucleus data where there nascent RNA is more abundant and poised for internal (largely intronic) priming. The longer the gene, the greater potential for priming that affects counts. And
RT @mike_schatz: Nice talk by John Chamberlin & @aaronquinlan discussing biases in scRNAseq due to intron counting. Recommends methods tha…
RT @mike_schatz: Nice talk by John Chamberlin & @aaronquinlan discussing biases in scRNAseq due to intron counting. Recommends methods tha…
Nice talk by John Chamberlin & @aaronquinlan discussing biases in scRNAseq due to intron counting. Recommends methods that can correct for gene-length biases such as GOseq (from @AliciaOshlack et al) https://t.co/Gkxqvbbkh2 #biodata20
RT @AliciaOshlack: This is the same bias addressed in our 2010 paper & GOSeq software. Here they propose normalisation of data using cqn be…
RT @AliciaOshlack: This is the same bias addressed in our 2010 paper & GOSeq software. Here they propose normalisation of data using cqn be…
RT @AliciaOshlack: This is the same bias addressed in our 2010 paper & GOSeq software. Here they propose normalisation of data using cqn be…
RT @AliciaOshlack: This is the same bias addressed in our 2010 paper & GOSeq software. Here they propose normalisation of data using cqn be…
RT @AliciaOshlack: This is the same bias addressed in our 2010 paper & GOSeq software. Here they propose normalisation of data using cqn be…
RT @AliciaOshlack: This is the same bias addressed in our 2010 paper & GOSeq software. Here they propose normalisation of data using cqn be…
Indeed would be nice if the 2019 paper would compare and contrast with the work from 2010 and cite the previous work . @TelAvivUni's @mandelboum Ran Elkon and colleagues 2019: https://t.co/mSocNjmt58 2010: https://t.co/snLlufZUYY
RT @AliciaOshlack: This is the same bias addressed in our 2010 paper & GOSeq software. Here they propose normalisation of data using cqn be…
RT @AliciaOshlack: This is the same bias addressed in our 2010 paper & GOSeq software. Here they propose normalisation of data using cqn be…
RT @AliciaOshlack: This is the same bias addressed in our 2010 paper & GOSeq software. Here they propose normalisation of data using cqn be…
@arjunsbaghela
RT @AliciaOshlack: This is the same bias addressed in our 2010 paper & GOSeq software. Here they propose normalisation of data using cqn be…
RT @AliciaOshlack: This is the same bias addressed in our 2010 paper & GOSeq software. Here they propose normalisation of data using cqn be…
RT @AliciaOshlack: This is the same bias addressed in our 2010 paper & GOSeq software. Here they propose normalisation of data using cqn be…
RT @AliciaOshlack: This is the same bias addressed in our 2010 paper & GOSeq software. Here they propose normalisation of data using cqn be…
RT @AliciaOshlack: This is the same bias addressed in our 2010 paper & GOSeq software. Here they propose normalisation of data using cqn be…
RT @AliciaOshlack: This is the same bias addressed in our 2010 paper & GOSeq software. Here they propose normalisation of data using cqn be…
RT @AliciaOshlack: This is the same bias addressed in our 2010 paper & GOSeq software. Here they propose normalisation of data using cqn be…
RT @AliciaOshlack: This is the same bias addressed in our 2010 paper & GOSeq software. Here they propose normalisation of data using cqn be…
RT @AliciaOshlack: This is the same bias addressed in our 2010 paper & GOSeq software. Here they propose normalisation of data using cqn be…
RT @AliciaOshlack: This is the same bias addressed in our 2010 paper & GOSeq software. Here they propose normalisation of data using cqn be…
RT @AliciaOshlack: This is the same bias addressed in our 2010 paper & GOSeq software. Here they propose normalisation of data using cqn be…
RT @AliciaOshlack: This is the same bias addressed in our 2010 paper & GOSeq software. Here they propose normalisation of data using cqn be…
RT @AliciaOshlack: This is the same bias addressed in our 2010 paper & GOSeq software. Here they propose normalisation of data using cqn be…
RT @AliciaOshlack: This is the same bias addressed in our 2010 paper & GOSeq software. Here they propose normalisation of data using cqn be…
RT @AliciaOshlack: This is the same bias addressed in our 2010 paper & GOSeq software. Here they propose normalisation of data using cqn be…
RT @AliciaOshlack: This is the same bias addressed in our 2010 paper & GOSeq software. Here they propose normalisation of data using cqn be…
RT @AliciaOshlack: This is the same bias addressed in our 2010 paper & GOSeq software. Here they propose normalisation of data using cqn be…
RT @AliciaOshlack: This is the same bias addressed in our 2010 paper & GOSeq software. Here they propose normalisation of data using cqn be…
RT @AliciaOshlack: This is the same bias addressed in our 2010 paper & GOSeq software. Here they propose normalisation of data using cqn be…
RT @AliciaOshlack: This is the same bias addressed in our 2010 paper & GOSeq software. Here they propose normalisation of data using cqn be…
RT @AliciaOshlack: This is the same bias addressed in our 2010 paper & GOSeq software. Here they propose normalisation of data using cqn be…
RT @AliciaOshlack: This is the same bias addressed in our 2010 paper & GOSeq software. Here they propose normalisation of data using cqn be…
RT @AliciaOshlack: This is the same bias addressed in our 2010 paper & GOSeq software. Here they propose normalisation of data using cqn be…
We should have a look on this @BuschLab
RT @AliciaOshlack: This is the same bias addressed in our 2010 paper & GOSeq software. Here they propose normalisation of data using cqn be…
RT @AliciaOshlack: This is the same bias addressed in our 2010 paper & GOSeq software. Here they propose normalisation of data using cqn be…
RT @AliciaOshlack: This is the same bias addressed in our 2010 paper & GOSeq software. Here they propose normalisation of data using cqn be…
RT @AliciaOshlack: This is the same bias addressed in our 2010 paper & GOSeq software. Here they propose normalisation of data using cqn be…
RT @AliciaOshlack: This is the same bias addressed in our 2010 paper & GOSeq software. Here they propose normalisation of data using cqn be…
RT @AliciaOshlack: This is the same bias addressed in our 2010 paper & GOSeq software. Here they propose normalisation of data using cqn be…
RT @AliciaOshlack: This is the same bias addressed in our 2010 paper & GOSeq software. Here they propose normalisation of data using cqn be…
RT @AliciaOshlack: This is the same bias addressed in our 2010 paper & GOSeq software. Here they propose normalisation of data using cqn be…
RT @AliciaOshlack: This is the same bias addressed in our 2010 paper & GOSeq software. Here they propose normalisation of data using cqn be…
RT @AliciaOshlack: This is the same bias addressed in our 2010 paper & GOSeq software. Here they propose normalisation of data using cqn be…
RT @AliciaOshlack: This is the same bias addressed in our 2010 paper & GOSeq software. Here they propose normalisation of data using cqn be…
RT @AliciaOshlack: This is the same bias addressed in our 2010 paper & GOSeq software. Here they propose normalisation of data using cqn be…
RT @AliciaOshlack: @EricTopol @TelAvivUni @mandelboum @PLOSBiology Our attempt to address this in 2010 with the goseq bioconductor package…
RT @AliciaOshlack: This is the same bias addressed in our 2010 paper & GOSeq software. Here they propose normalisation of data using cqn be…
RT @AliciaOshlack: This is the same bias addressed in our 2010 paper & GOSeq software. Here they propose normalisation of data using cqn be…
This is the same bias addressed in our 2010 paper & GOSeq software. Here they propose normalisation of data using cqn before gene set testing. We developed a set testing method that corrects empirical bias. Wld be nice to compare https://t.co/TaHNUZhc8
RT @AliciaOshlack: @EricTopol @TelAvivUni @mandelboum @PLOSBiology Our attempt to address this in 2010 with the goseq bioconductor package…
@EricTopol @TelAvivUni @mandelboum @PLOSBiology Our attempt to address this in 2010 with the goseq bioconductor package @constantAmateur @genomematt @GenomeBiology https://t.co/TaHNUZhc8B
Bookmarking,
@szintri @gbaucom @kheyduk @JBYoder GOseq https://t.co/2UoVDd78oD accounts for this bias by weighting genes instead of binning. It uses transcript length instead of total expression as a proxy for detection bias to avoid over-correction, but can use either
RT @AliciaOshlack: My first senior author paper was published on this day 6 years ago GOseq https://t.co/L56X7BaMQF @GenomeBiology
RT @AliciaOshlack: My first senior author paper was published on this day 6 years ago GOseq https://t.co/L56X7BaMQF @GenomeBiology
RT @AliciaOshlack: My first senior author paper was published on this day 6 years ago GOseq https://t.co/L56X7BaMQF @GenomeBiology
RT @AliciaOshlack: My first senior author paper was published on this day 6 years ago GOseq https://t.co/L56X7BaMQF @GenomeBiology
My first senior author paper was published on this day 6 years ago GOseq https://t.co/L56X7BaMQF @GenomeBiology
Gene ontology analysis for RNA-seq: accounting for selection bias http://t.co/U8dZF4J6R8
Gene ontology analysis for RNA-seq: accounting for selection bias http://t.co/U8dZF4J6R8
Gene ontology analysis for RNA-seq: accounting for selection bias http://t.co/U8dZF4J6R8