| Title |
Meta-analysis: proton pump inhibitors moderately increase the risk of small intestinal bacterial overgrowth
|
|---|---|
| Published in |
Journal of Gastroenterology, August 2017
|
| DOI | 10.1007/s00535-017-1371-9 |
| Pubmed ID | |
| Authors |
Tingting Su, Sanchuan Lai, Allen Lee, Xingkang He, Shujie Chen |
| Abstract |
The use of proton pump inhibitors (PPIs) may potentially predispose to the development of small intestinal bacterial overgrowth (SIBO), but this association is controversial due to conflicting results from studies conducted to date. The aim of this meta-analysis was to evaluate the association between the use of PPIs and the risk of SIBO. We systematically searched the online PubMed, Embase, and Cochrane Library databases and Web of Science for relevant articles published up to November 2016. Two researchers identified and extracted data independent of each other. The pooled analysis was performed using the generic inverse-variance random-effects model. Subgroup and sensitivity analysis were conducted to assess the stability and heterogeneity of the pooled results. The risk of publication bias was evaluated by assessing for funnel plot asymmetry and by Egger's test and Begg's test. A total of 19 articles met the eligibility criteria for the meta-analysis, reporting on 7055 subjects. The pooled odds ratio (OR) showed a statistically significant association between increased risk of SIBO and PPI use (OR 1.71, 95% confidence interval 1.20-2.43). Subgroup analyses demonstrated an association between SIBO and PPI use in studies that employed small bowel aspirates culture and glucose hydrogen breath tests (GHBT) as diagnostic tests for SIBO. Our meta-analysis suggests that the use of PPI moderately increases the risk of SIBO, thereby highlighting the need for appropriate prescribing of PPIs. |
X Demographics
The data shown below were collected from the profiles of 19 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 7 | 37% |
| United Kingdom | 3 | 16% |
| Japan | 2 | 11% |
| Brazil | 1 | 5% |
| Australia | 1 | 5% |
| Unknown | 5 | 26% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 12 | 63% |
| Practitioners (doctors, other healthcare professionals) | 5 | 26% |
| Science communicators (journalists, bloggers, editors) | 1 | 5% |
| Scientists | 1 | 5% |
Mendeley readers
The data shown below were compiled from readership statistics for 119 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 119 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 15 | 13% |
| Researcher | 12 | 10% |
| Student > Bachelor | 11 | 9% |
| Student > Doctoral Student | 9 | 8% |
| Other | 8 | 7% |
| Other | 23 | 19% |
| Unknown | 41 | 34% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 34 | 29% |
| Nursing and Health Professions | 12 | 10% |
| Biochemistry, Genetics and Molecular Biology | 6 | 5% |
| Agricultural and Biological Sciences | 5 | 4% |
| Immunology and Microbiology | 4 | 3% |
| Other | 11 | 9% |
| Unknown | 47 | 39% |
Attention Score in Context
This research output has an Altmetric Attention Score of 29. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 July 2023.
All research outputs
#1,403,853
of 25,923,151 outputs
Outputs from Journal of Gastroenterology
#34
of 1,289 outputs
Outputs of similar age
#27,051
of 331,654 outputs
Outputs of similar age from Journal of Gastroenterology
#1
of 20 outputs
Altmetric has tracked 25,923,151 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,289 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.4. This one has done particularly well, scoring higher than 97% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 331,654 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 91% of its contemporaries.
We're also able to compare this research output to 20 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 95% of its contemporaries.