Title |
Epstein–Barr virus and rheumatoid arthritis: is there a link?
|
---|---|
Published in |
Arthritis Research & Therapy, January 2006
|
DOI | 10.1186/ar1893 |
Pubmed ID | |
Authors |
Karen H Costenbader, Elizabeth W Karlson |
Abstract |
Rheumatoid arthritis is a systemic autoimmune disease characterized by chronic, destructive, debilitating arthritis. Its etiology is unknown; it is presumed that environmental factors trigger development in the genetically predisposed. Epstein-Barr virus, a nearly ubiquitous virus in the human population, has generated great interest as a potential trigger. This virus stimulates polyclonal lymphocyte expansion and persists within B lymphocytes for the host's life, inhibited from reactivating by the immune response. In latent and replicating forms, it has immunomodulating actions that could play a role in the development of this autoimmune disease. The evidence linking Epstein-Barr virus and rheumatoid arthritis is reviewed. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Netherlands | 3 | 3% |
Ireland | 1 | 1% |
Sweden | 1 | 1% |
United Kingdom | 1 | 1% |
Japan | 1 | 1% |
United States | 1 | 1% |
Unknown | 89 | 92% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 22 | 23% |
Researcher | 15 | 15% |
Student > Ph. D. Student | 14 | 14% |
Student > Master | 10 | 10% |
Other | 6 | 6% |
Other | 15 | 15% |
Unknown | 15 | 15% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 37 | 38% |
Biochemistry, Genetics and Molecular Biology | 19 | 20% |
Agricultural and Biological Sciences | 13 | 13% |
Immunology and Microbiology | 6 | 6% |
Nursing and Health Professions | 1 | 1% |
Other | 5 | 5% |
Unknown | 16 | 16% |