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Telomeres, senescence, and hematopoietic stem cells

Overview of attention for article published in Cell & Tissue Research, October 2007
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Title
Telomeres, senescence, and hematopoietic stem cells
Published in
Cell & Tissue Research, October 2007
DOI 10.1007/s00441-007-0469-4
Pubmed ID
Authors

Stefan Zimmermann, Uwe M. Martens

Abstract

The replicative lifespan of normal somatic cells is restricted by the erosion of telomeres, which are protective caps at the ends of linear chromosomes. The loss of telomeres induces antiproliferative signals that eventually lead to cellular senescence. The enzyme complex telomerase can maintain telomeres, but its expression is confined to highly proliferative cells such as stem cells and tumor cells. The immense regenerative capacity of the hematopoietic system is provided by a distinct type of adult stem cell: hematopoietic stem cells (HSCs). Although blood cells have to be produced continuously throughout life, the HSC pool seems not to be spared by aging processes. Indeed, limited expression of telomerase is not sufficient to prevent telomere shortening in these cells, which is thought ultimately to limit their proliferative capacity. In this review, we discuss the relevance of telomere maintenance for the hematopoietic stem cell compartment and consider potential functions of telomerase in this context. We also present possible clinical applications of telomere manipulation in HSCs and new insights affecting the aging of the hematopoietic stem cell pool and replicative exhaustion.

Mendeley readers

The data shown below were compiled from readership statistics for 52 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 3 6%
Mexico 1 2%
United Kingdom 1 2%
Unknown 47 90%

Demographic breakdown

Readers by professional status Count As %
Researcher 13 25%
Student > Ph. D. Student 13 25%
Student > Master 6 12%
Student > Postgraduate 4 8%
Professor 3 6%
Other 13 25%
Readers by discipline Count As %
Agricultural and Biological Sciences 26 50%
Biochemistry, Genetics and Molecular Biology 11 21%
Medicine and Dentistry 5 10%
Unspecified 4 8%
Immunology and Microbiology 3 6%
Other 3 6%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 May 2014.
All research outputs
#10,839,562
of 12,228,143 outputs
Outputs from Cell & Tissue Research
#1,336
of 1,535 outputs
Outputs of similar age
#164,166
of 198,268 outputs
Outputs of similar age from Cell & Tissue Research
#35
of 44 outputs
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So far Altmetric has tracked 1,535 research outputs from this source. They receive a mean Attention Score of 2.6. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 44 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.