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Telomeres, senescence, and hematopoietic stem cells

Overview of attention for article published in Cell and Tissue Research, October 2007
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Title
Telomeres, senescence, and hematopoietic stem cells
Published in
Cell and Tissue Research, October 2007
DOI 10.1007/s00441-007-0469-4
Pubmed ID
Authors

Stefan Zimmermann, Uwe M. Martens

Abstract

The replicative lifespan of normal somatic cells is restricted by the erosion of telomeres, which are protective caps at the ends of linear chromosomes. The loss of telomeres induces antiproliferative signals that eventually lead to cellular senescence. The enzyme complex telomerase can maintain telomeres, but its expression is confined to highly proliferative cells such as stem cells and tumor cells. The immense regenerative capacity of the hematopoietic system is provided by a distinct type of adult stem cell: hematopoietic stem cells (HSCs). Although blood cells have to be produced continuously throughout life, the HSC pool seems not to be spared by aging processes. Indeed, limited expression of telomerase is not sufficient to prevent telomere shortening in these cells, which is thought ultimately to limit their proliferative capacity. In this review, we discuss the relevance of telomere maintenance for the hematopoietic stem cell compartment and consider potential functions of telomerase in this context. We also present possible clinical applications of telomere manipulation in HSCs and new insights affecting the aging of the hematopoietic stem cell pool and replicative exhaustion.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 75 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 3 4%
Mexico 1 1%
United Kingdom 1 1%
Unknown 70 93%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 16 21%
Researcher 14 19%
Student > Master 10 13%
Student > Bachelor 6 8%
Student > Postgraduate 4 5%
Other 11 15%
Unknown 14 19%
Readers by discipline Count As %
Agricultural and Biological Sciences 30 40%
Biochemistry, Genetics and Molecular Biology 17 23%
Medicine and Dentistry 5 7%
Immunology and Microbiology 3 4%
Chemistry 2 3%
Other 3 4%
Unknown 15 20%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 May 2014.
All research outputs
#21,178,329
of 23,839,820 outputs
Outputs from Cell and Tissue Research
#2,002
of 2,279 outputs
Outputs of similar age
#75,096
of 77,713 outputs
Outputs of similar age from Cell and Tissue Research
#15
of 16 outputs
Altmetric has tracked 23,839,820 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,279 research outputs from this source. They receive a mean Attention Score of 3.3. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 77,713 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 16 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.