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Assessment of packed bed bioreactor systems in the production of viral vaccines

Overview of attention for article published in AMB Express, April 2014
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  • Good Attention Score compared to outputs of the same age (70th percentile)

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1 tweeter
1 patent


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69 Mendeley
Assessment of packed bed bioreactor systems in the production of viral vaccines
Published in
AMB Express, April 2014
DOI 10.1186/s13568-014-0025-z
Pubmed ID

Ramya Rajendran, Rajendra Lingala, Siva Kumar Vuppu, Bala Obulapathi Bandi, Elaiyaraja Manickam, Sankar Rao Macherla, Stéphanie Dubois, Nicolas Havelange, Kapil Maithal


Vaccination is believed to be the most effective method for the prevention of infectious diseases. Thus it is imperative to develop cost effective and scalable process for the production of vaccines so as to make them affordable for mass use. In this study, performance of a novel disposable iCELLis fixed bed bioreactor system was investigated for the production of some viral vaccines like Rabies, Hepatitis-A and Chikungunya vaccines in comparison to conventional systems like the commercially available packed bed system and roller bottle system. Vero and MRC-5 cell substrates were evaluated for growth parameters in all the three systems maintaining similar seeding density, multiplicity of infection (MOI) and media components. It was observed that Vero cells showed similar growth in all the three bioreactors whereas MRC-5 cells showed better growth in iCELLis Nano system and roller bottle system. Subsequently, the virus infection and antigen production studies also revealed that for Hepatitis-A and Chikungunya iCELLis Nano bioreactor system was better to the commercial packed bed bioreactor and roller bottle systems. Although for rabies antigen production commercially available packed bed bioreactor system was found to be better. This study shows that different bioreactor platforms may be employed for viral vaccine production and iCELLis Nano is one of such new convenient and a stable platform for production of human viral vaccines.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 69 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 1%
Unknown 68 99%

Demographic breakdown

Readers by professional status Count As %
Researcher 16 23%
Student > Master 9 13%
Student > Bachelor 8 12%
Student > Ph. D. Student 6 9%
Student > Postgraduate 4 6%
Other 11 16%
Unknown 15 22%
Readers by discipline Count As %
Agricultural and Biological Sciences 10 14%
Biochemistry, Genetics and Molecular Biology 8 12%
Engineering 8 12%
Medicine and Dentistry 5 7%
Immunology and Microbiology 3 4%
Other 18 26%
Unknown 17 25%

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 August 2018.
All research outputs
of 14,818,787 outputs
Outputs from AMB Express
of 932 outputs
Outputs of similar age
of 189,141 outputs
Outputs of similar age from AMB Express
of 3 outputs
Altmetric has tracked 14,818,787 research outputs across all sources so far. This one has received more attention than most of these and is in the 69th percentile.
So far Altmetric has tracked 932 research outputs from this source. They receive a mean Attention Score of 2.1. This one has done well, scoring higher than 88% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 189,141 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.
We're also able to compare this research output to 3 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them