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Characterization and Inflammatory Response of Perivascular-Resident Macrophage-Like Melanocytes in the Vestibular System

Overview of attention for article published in Journal of the Association for Research in Otolaryngology : JARO, July 2013
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Title
Characterization and Inflammatory Response of Perivascular-Resident Macrophage-Like Melanocytes in the Vestibular System
Published in
Journal of the Association for Research in Otolaryngology : JARO, July 2013
DOI 10.1007/s10162-013-0403-2
Pubmed ID
Authors

Fei Zhang, Jinhui Zhang, Lingling Neng, Xiaorui Shi

Abstract

A large number of perivascular cells expressing both macrophage and melanocyte characteristics (named perivascular-resident macrophage-like melanocytes, PVM/Ms), previously found in the intra-strial fluid-blood barrier, are also found in the blood-labyrinth barrier area of the vestibular system in normal adult cochlea, including in the three ampullae of the semicircular canals (posterior, superior, and horizontal), utricle, and saccule. The cells were identified as PVM/Ms, positive for the macrophage and melanocyte marker proteins F4/80 and GSTα4. Similar to PVM/Ms present in the stria vascularis, the PVM/Ms in the vestibular system are closely associated with microvessels and structurally intertwined with endothelial cells and pericytes, with a density in normal (unstimulated) utricle of 225 ± 43/mm(2); saccule 191 ± 25/mm(2); horizontal ampullae 212 ± 36/mm(2); anterior ampullae 238 ± 36/mm(2); and posterior ampullae 223 ± 64/mm(2). Injection of bacterial lipopolysaccharide into the middle ear through the tympanic membrane causes the PVM/Ms to activate and arrange in an irregular pattern along capillary walls in all regions within a 48-h period. The inflammatory response significantly increases vascular permeability and leakage. The results underscore the morphological complexity of the blood barrier in the vestibular system, with its surrounding basal lamina, pericytes, as well as second line of defense in PVM/Ms. PVM/Ms may be important to maintain blood barrier integrity and initiating local inflammatory response in the vestibular system.

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Mendeley readers

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Geographical breakdown

Country Count As %
Germany 1 5%
Korea, Republic of 1 5%
Unknown 20 91%

Demographic breakdown

Readers by professional status Count As %
Researcher 8 36%
Other 3 14%
Student > Ph. D. Student 3 14%
Student > Postgraduate 2 9%
Professor > Associate Professor 2 9%
Other 4 18%
Readers by discipline Count As %
Medicine and Dentistry 9 41%
Agricultural and Biological Sciences 6 27%
Unspecified 1 5%
Computer Science 1 5%
Nursing and Health Professions 1 5%
Other 4 18%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 April 2014.
All research outputs
#11,363,556
of 12,776,571 outputs
Outputs from Journal of the Association for Research in Otolaryngology : JARO
#234
of 262 outputs
Outputs of similar age
#157,876
of 189,602 outputs
Outputs of similar age from Journal of the Association for Research in Otolaryngology : JARO
#6
of 6 outputs
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