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Analysis of a uteroglobin gene polymorphism in childhood Henoch–Schonlein purpura

Overview of attention for article published in Pediatric Nephrology, April 2006
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Title
Analysis of a uteroglobin gene polymorphism in childhood Henoch–Schonlein purpura
Published in
Pediatric Nephrology, April 2006
DOI 10.1007/s00467-006-0094-6
Pubmed ID
Authors

Eli M. Eisenstein, Moonsuk Choi

Abstract

Uteroglobin (UG) is a pleiotropic protein with anti-inflammatory properties. Mice rendered genetically incapable of expressing UG develop a form of renal disease that closely resembles human IgA nephropathy (IgAN). Furthermore, a single nucleotide polymorphism in the UG gene (A38G) has been associated with rapid progression of human IgAN. We examined whether the A38G polymorphism is associated with childhood Henoch-Schonlein purpura (HSP), a form of vasculitis associated with IgAN-like renal disease. We examined the prevalence of the A38G polymorphism in 34 children with HSP and in 38 ethnically matched controls. Only one patient had clinically evident renal involvement. As compared with controls, the prevalence of the 38G allele was slightly increased in children with HSP, but this increase was not statistically significant. Our results do not support a role for UG in susceptibility to childhood HSP in the population studied. Larger studies involving more patients with renal disease will be necessary to define whether UG is associated with increased risk for HSP nephritis.

Mendeley readers

The data shown below were compiled from readership statistics for 4 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 4 100%

Demographic breakdown

Readers by professional status Count As %
Student > Postgraduate 2 50%
Student > Master 1 25%
Researcher 1 25%
Readers by discipline Count As %
Medicine and Dentistry 4 100%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 June 2006.
All research outputs
#2,018,187
of 3,635,050 outputs
Outputs from Pediatric Nephrology
#261
of 581 outputs
Outputs of similar age
#21,935
of 51,753 outputs
Outputs of similar age from Pediatric Nephrology
#2
of 8 outputs
Altmetric has tracked 3,635,050 research outputs across all sources so far. This one is in the 26th percentile – i.e., 26% of other outputs scored the same or lower than it.
So far Altmetric has tracked 581 research outputs from this source. They receive a mean Attention Score of 1.7. This one is in the 19th percentile – i.e., 19% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 51,753 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 43rd percentile – i.e., 43% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 8 others from the same source and published within six weeks on either side of this one. This one has scored higher than 6 of them.