| Title |
Identification of novel prostate cancer drivers using RegNetDriver: a framework for integration of genetic and epigenetic alterations with tissue-specific regulatory network
|
|---|---|
| Published in |
Genome Biology, July 2017
|
| DOI | 10.1186/s13059-017-1266-3 |
| Pubmed ID | |
| Authors |
Priyanka Dhingra, Alexander Martinez-Fundichely, Adeline Berger, Franklin W. Huang, Andre Neil Forbes, Eric Minwei Liu, Deli Liu, Andrea Sboner, Pablo Tamayo, David S. Rickman, Mark A. Rubin, Ekta Khurana |
| Abstract |
We report a novel computational method, RegNetDriver, to identify tumorigenic drivers using the combined effects of coding and non-coding single nucleotide variants, structural variants, and DNA methylation changes in the DNase I hypersensitivity based regulatory network. Integration of multi-omics data from 521 prostate tumor samples indicated a stronger regulatory impact of structural variants, as they affect more transcription factor hubs in the tissue-specific network. Moreover, crosstalk between transcription factor hub expression modulated by structural variants and methylation levels likely leads to the differential expression of target genes. We report known prostate tumor regulatory drivers and nominate novel transcription factors (ERF, CREB3L1, and POU2F2), which are supported by functional validation. |
X Demographics
The data shown below were collected from the profiles of 30 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 10 | 33% |
| United Kingdom | 2 | 7% |
| Switzerland | 2 | 7% |
| Israel | 1 | 3% |
| Singapore | 1 | 3% |
| India | 1 | 3% |
| France | 1 | 3% |
| Denmark | 1 | 3% |
| Germany | 1 | 3% |
| Other | 4 | 13% |
| Unknown | 6 | 20% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 18 | 60% |
| Members of the public | 11 | 37% |
| Science communicators (journalists, bloggers, editors) | 1 | 3% |
Mendeley readers
The data shown below were compiled from readership statistics for 74 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 74 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 27 | 36% |
| Researcher | 16 | 22% |
| Student > Master | 8 | 11% |
| Student > Bachelor | 7 | 9% |
| Professor | 4 | 5% |
| Other | 7 | 9% |
| Unknown | 5 | 7% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 33 | 45% |
| Agricultural and Biological Sciences | 15 | 20% |
| Medicine and Dentistry | 6 | 8% |
| Computer Science | 5 | 7% |
| Engineering | 3 | 4% |
| Other | 3 | 4% |
| Unknown | 9 | 12% |
Attention Score in Context
This research output has an Altmetric Attention Score of 27. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 April 2018.
All research outputs
#1,434,607
of 25,382,440 outputs
Outputs from Genome Biology
#1,140
of 4,468 outputs
Outputs of similar age
#28,122
of 327,247 outputs
Outputs of similar age from Genome Biology
#23
of 63 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,468 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 27.6. This one has gotten more attention than average, scoring higher than 74% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 327,247 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 91% of its contemporaries.
We're also able to compare this research output to 63 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 63% of its contemporaries.