| Title |
Microglial depletion and activation: A [11C]PBR28 PET study in nonhuman primates
|
|---|---|
| Published in |
EJNMMI Research, July 2017
|
| DOI | 10.1186/s13550-017-0305-0 |
| Pubmed ID | |
| Authors |
Ansel T. Hillmer, Daniel Holden, Krista Fowles, Nabeel Nabulsi, Brian L. West, Richard E. Carson, Kelly P. Cosgrove |
| Abstract |
The 18-kDa translocator protein (TSPO) is an important target for assessing neuroimmune function in brain with positron-emission tomography (PET) imaging. The goal of this work was to assess two [(11)C]PBR28 imaging paradigms for measuring dynamic microglia changes in Macaca mulatta. Dynamic [(11)C]PBR28 PET imaging data with arterial blood sampling were acquired to quantify TSPO levels as [(11)C]PBR28 V T. Scans were acquired at three timepoints: baseline, immediately post-drug, and prolonged post-drug. In one animal, a colony-stimulating factor 1 receptor kinase inhibitor, previously shown to deplete brain microglia, reduced [(11)C]PBR28 V T in brain by 46 ± 3% from baseline, which recovered after 12 days to 7 ± 5% from baseline. In a different animal, acute lipopolysaccharide administration, shown to activate brain microglia, increased [(11)C]PBR28 V T in brain by 39 ± 9% from baseline, which recovered after 14 days to -11 ± 3% from baseline. These studies provide preliminary evidence of complementary paradigms to assess microglia dynamics via in vivo TSPO imaging. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 50% |
| Members of the public | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 49 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 49 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 16 | 33% |
| Researcher | 11 | 22% |
| Student > Master | 3 | 6% |
| Student > Bachelor | 3 | 6% |
| Other | 2 | 4% |
| Other | 3 | 6% |
| Unknown | 11 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 9 | 18% |
| Neuroscience | 8 | 16% |
| Immunology and Microbiology | 4 | 8% |
| Agricultural and Biological Sciences | 3 | 6% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 4% |
| Other | 8 | 16% |
| Unknown | 15 | 31% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 May 2020.
All research outputs
#15,814,901
of 23,486,774 outputs
Outputs from EJNMMI Research
#270
of 575 outputs
Outputs of similar age
#200,625
of 317,506 outputs
Outputs of similar age from EJNMMI Research
#4
of 10 outputs
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