Title |
On the road to bioartificial organs
|
---|---|
Published in |
Pflügers Archiv - European Journal of Physiology, April 2014
|
DOI | 10.1007/s00424-014-1504-4 |
Pubmed ID | |
Authors |
X. Ren, H. C. Ott |
Abstract |
Biological organs are highly orchestrated systems with well-coordinated positioning, grouping, and interaction of different cell types within their specialized extracellular environment. Bioartificial organs are intended to be functional replacements of native organs generated through bioengineering techniques and hold the potential to alleviate donor organ shortage for transplantation. The development, production, and evaluation of such bioartificial organs require synergistic efforts of biology, material science, engineering, and medicine. In this review, we highlight the emerging platforms enabling structured assembly of multiple cell types into functional grafts and discuss recent advances and challenges in the development of bioartificial organs, including cell sources, in vitro organ culture, in vivo evaluation, and clinical considerations. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 50% |
Practitioners (doctors, other healthcare professionals) | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Croatia | 1 | 1% |
Germany | 1 | 1% |
Brazil | 1 | 1% |
Unknown | 66 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 12 | 17% |
Student > Master | 10 | 14% |
Student > Bachelor | 10 | 14% |
Student > Ph. D. Student | 8 | 12% |
Other | 5 | 7% |
Other | 12 | 17% |
Unknown | 12 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Engineering | 14 | 20% |
Agricultural and Biological Sciences | 11 | 16% |
Medicine and Dentistry | 9 | 13% |
Biochemistry, Genetics and Molecular Biology | 8 | 12% |
Materials Science | 5 | 7% |
Other | 9 | 13% |
Unknown | 13 | 19% |